I-Oleoylethanolamide (OEA): Umuthi Wokulahlekelwa Isisindo Osiza Ukulawula Iphango

Yini i-Oleoylethanolamide (OEA)?

Oleoylethanolamide (I-OEA) isilawuli semvelo sesisindo, i-cholesterol, nesifiso sokudla. I-metabolite ihlanganiswa ngamanani amancane emathunjini amancane. Imolekyuli yemvelo inesibopho somuzwa wokugcwala ngemuva kokudla. I-Oleoylethanolamide isiza ekulawuleni amafutha omzimba ngokubophezela kwi-Peroxisome proliferator-activated receptor alpha (PPAR-Alpha). Le metabolite yemvelo ithuthukisa imetabolism yomzimba womzimba futhi yazisa ubuchopho bakho ukuthi uthathe ukudla okwanele futhi kufanele uyeke ukudla. I-Oleoylethanolamide ibuye inyuse izindleko ezingahlobene nokuzivocavoca ezihlobene nokusebenza.

Isebenza kanjani i-Oleoylethanolamide (OEA)?

I-Oleoylethanolamide (OEA) Mechanism yesenzo

I-Oleoylethanolamide (I-OEA) isebenza njenge- isifiso sokulawula. I-Oleoylethanolamide ilawula ukungena kwakho kokudla ngokuthumela amasiginali ebuchosheni ikwazisa ukuthi ugcwele, futhi sekuyisikhathi sokuyeka ukudla. Ngenxa yalokhu, uthatha ukudla okuncane nsuku zonke, futhi umzimba wakho uyeka ukupakisha isisindo esithe xaxa.

Oleoylethanolamide (OEA) (111-58-0) kukhiqizwa futhi kuhlanganiswe emathunjini amancane kusuka ku-oleic acid ethathwe ekudleni. Ukudla okunamafutha amaningi kungavimbela ukukhiqizwa kwe-Oleoylethanolamide emathunjini amancane.

I-Oleoylethanolamide yehlisa ukungena kokudla ngokuvuselela ukujikeleza kwengqondo kwe-histamine, i-oosttocin ye-homeostatic, kanye ne-hedonic dopamine pathways. Kuyabonakala ukuthi i-Oleoylethanolamide nayo ingathola ukusayina kwe-CB1R, okuthe uma kuvuselelwa kungaholela ekwandiseni ukudla. I-Oleoylethanolamide inciphisa ukuthuthwa kwe-lipid kuma-adipocytes ukwehlisa isisindo samafutha.

I-OEA isebenza futhi ukuvuselela okuthile okwaziwa ngokuthi yi-PPAR futhi ngesikhathi esifanayo kwehlisa ukugcinwa kwamafutha futhi kwandise ukushiswa kwamafutha. Noma nini lapho udla, amazinga e-OEA akhuphuka futhi isifiso sakho sokudla siyawa. Lokhu kwenzeka ngoba izinzwa zemizwa ezixhunywe ebuchosheni bakho ziyazisa ukuthi ubonga ngokuphelele ku-PPAR-α. I-PPAR-α iyi-receptor yenuzi ene-ligand-activated ebandakanyeka ezindleleni zamandla we-homeostasis kanye nencazelo yohlobo lwe-lipid metabolism.

I-Oleoylethanolamide (OEA) ikhombisa zonke izici ezichaza isici siciety esifaka:

• Ukuvimbela ukondla ngokwandisa isikhathi sokuphakathi kokudla okukodwa esidlweni esilandelayo;
• Ukukhiqizwa kwayo kulawulwa ukutholakala kwezakhi zomzimba
• Amazinga ayo aya ngokuya ngokuguquguquka kwesekethe.

Izinzuzo ze-Oleoylethanolamide (OEA)

Izinzuzo ze-Oleoylethanolamide futhi imiphumela yokuncipha kwesisindo ifaka;

i. Ukunciphisa inkanuko evusa inkanuko eyaziwa ngokuthi i-Ghrelin

Imijovo ye-Peripheral ye-OEA enikezwe amagundane ebikade izila ukudla ngosuku oluthile ayizange ibe nomthelela kuma-ghrelin hormone kungakapheli nemizuzu engama-120, kodwa ngemuva kwamahora ayisithupha kwaba nokwehla okumangazayo kule hormone ngamaphesenti angama-6 kuye kwangama-40. Kodwa-ke, i-Oleoylethanolamide ayizange ibe nemiphumela ekugxileni kwalesi sikhathi sokudla eshukumisa inhliziyo i-hormone ezindongeni ezondlekile. Lokhu kusikisela ukuthi i-OEA supplement isebenza kangcono ekwehliseni amazinga e-ghrelin uma ithathwa ngaphambi kokudla.

ii. Ukunyusa izinga lokulahleka kwamafutha omzimba

Ama-receptors we-βeta-adrenergic receptors asebenza ukuvuselela ukulahleka kwesisindo somzimba kanye nokukhuthaza i-βeta3-adrenergic receptor ivumela ukwehla kokudla futhi inyuse ukulahleka kwamafutha kumagundane. I-receptor ikwenza ngokuvuselela amaprotheni angenazinkinga afaka i-UCP1.

Ngenxa yalokhu, ukusebenzisana ngokubambisana kwe-β3 agonist kanye ne-oleoylethanolamide injection peripheral kubonakala kusebenza ekunciphiseni ukudla okudliwayo futhi kusebenza kahle ekwehliseni isisindo samafutha esihambisana nokukhuphuka kokusetshenziswa kwamandla. Ukukhuphuka kwamazinga e-UCP1 ne-PPARα (okucatshangwa ukuthi kukhombisa ukusetshenziswa kwemali okusetshenziswayo) kwenzeka kuzicubu zombala ezinombala ezimhlophe nezimhlophe eceleni kwezithuthukisi kuma-biomarker e-mitochondrial.

Ngakho-ke i-OEA ibonakala ithuthukisa imiphumela ye-mitochondrial metabolism kanye nezenzo ze-thermogenic kuma-rodents kuzo zombili izicubu ezinsundu nezomhlophe, endaweni efanayo ye-oleoylethanolamide.

Iii. Ukwehlisela Izinga le-Peptide YY (i-Hetone-Stimulating Hormone)

Ukujova kwe-5mg / kg i-Oleoylethanolamide kumagundane kudale ukwehla okuxhomeke esikhathini ku-hormone peptide YY ekhiqizwa emathunjini kuwo womabili amazwe aphakanyisiwe nawokudla ukudla.

Ingabe i-Oleoylethanolamide (OEA) Isiza Ukulawula Iphango?

Yebo. I-Oleoylethanolamide isengezo sokunciphisa umzimba iyasiza lawula iphango ngokwenza kusebenze i-PPAR ngaleyo ndlela kunciphisa ukugcinwa kwamafutha nokwanda kokushiswa kwamafutha. Uma udla ukudla kwakho, amazinga e-Oleoylethanolamide ayakhuphuka kanye nokudla kwakho okuphansi lapho amasignali athunyelwa ebuchosheni bakho azisa ubuchopho ukuthi wenelisekile.

Kube nezifundo eziningana zesayensi ezifakazela lokhu. Isibonelo, ngo-2004, abacwaningi baseDenmark bafunda amagundane ayephungulwe usuku lunye. Babanikeza i-OEA futhi babona ukuthi inani lokudla abalithathayo lehlile ngo-15.5%. Ngamagama alula, i-Oleoylethanolamide (OEA) icima inkinobho yokulamba kwi-CNS (Central Nervous System).

I-Oleoylethanolamide (OEA) Umthamo

Umuthi onconyiwe we-oleoylethanolamide ungomunye we-capsule 200mg lapho uthathwa ngaphandle kwenhlanganisela. Lapho kuhlanganiswa nezinye izithasiselo zokuncipha kwesisindo, umthamo we-OEA kufanele wehliselwe phakathi kuka-100mg no-150mg.

Kuphakanyiswa ukuthi uthathe i-oleoylethanolamide engeza imizuzu engama-30 ngaphambi kokudla kwakusihlwa noma isidlo sasekuseni; uzozizwa waneliseke kakhudlwana ngesikhathi sakho sokudla bese ugcina ngokudla okuncane.

Ucwaningo lukhombisa ukuthi ungangehlisa noma ukhuphule imithamo yansuku zonke ngokuya nge-bodyweight yakho. Isibonelo, uma unesisindo esingu-150lb, ungathatha i-100mg. Umuntu we-200lb angathatha i-150mg kanti umuntu ongu-250lb angathatha u-180mg wesengezo.

Imiphumela ye-Oleoylethanolamide (OEA)

Imiphumela emibi ye-Oleoylethanolamide kungaba ukukhathazeka okukhulu phakathi kwabakhiqizi abengezayo abafuna ukufaka lesi sithako esinamandla kwifomula yokulahlekelwa kwesisindo yabo.

Ngemuva kokubuyekezwa okujulile kwayo yonke imininingwane yesayensi etholakalayo, i-US FDA (Ukudla Nezidakamizwa) yayingenazinkinga eziphathelene nokuphepha kwale molekyuli yemvelo. I-RiduZone yayingowokuqala u-OEA powder owabekwa uphawu ngo-2015.

I-OEA yi-oleic acid metabolite futhi iyingxenye yokudla okunempilo kwansuku zonke. Kuphephile ngokuphelele ukuthatha isengezo se-Oleoylethanolamide ngoba akukho miphumela emibi ebikiwe kuze kube manje.

Oleoylethanolamide (OEA) Thenga

Ungathola ukuthenga kwe-oleoylethanolamide ezitolo eziningana zezidakamizwa eziku-inthanethi nezomzimba. Kodwa-ke kuzodingeka uqaphele ngoba akubona bonke abaphakeli abathembekile. Qiniseka ukuthi ufunda izibuyekezo zabo ze-oleoylethanolamide ukwazi ukuthi yini ulwazi lwabathengi babo bangaphambili.

Ngabe uzibuza ukuthi ingathengiswa kuphi i-oleoylethanolamide? Ungakhathazeki; ungathenga i-oleoylethanolamide online lapha kuwebhusayithi yethu. Singabantu abadumile futhi abanolwazi I-OEA umphakeli futhi sinekhono lokuletha i-Oleoylethanolamide (OEA) e-USA nakwamanye amazwe amaningi emhlabeni jikelele. Inqubo yethu yoku-oda ilula kepha ivikeleke ngokuphelele futhi iphephile. Siphinde silethe imikhiqizo yethu ngamaphakeji avalwe kahle futhi amahle ukuqinisekisa ukuphepha nokugwema noma yikuphi ukungcola.

Isihloko ngu:

UDkt Liang

Co-founder, ubuholi benkampani obuyinhloko bokuphatha I-PhD itholwe kuFudan University ku-organic chemistry Isipiliyoni seminyaka engaphezu kwesishiyagalolunye emkhakheni we-organic synthesis wemithi yokwelapha. Isipiliyoni esicebile kumakhemikhali ahlanganisayo, chemistry yezokwelapha kanye nokwenziwa ngokwezifiso nokuphathwa kwephrojekthi

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