I-Alpha-lipoic Acid powder (1077-28-7)

I-Alfa-lipoic Acid powder Base Information

Igama	I-Alpha-lipoic Acid powder
CAS	1077-28-7
Ukuhlanzeka	98%
Igama lamakhemikhali	(+/-) - 1,2-Dithiolane-3-pentanoic Acid; (+/-) - 1,2-Dithiolane-3-valeric Acid; (+/-) - I-Alpha-lipoic Acid / Thioctic acid; (RS) -a-Lipoic Acid
omqondofana	I-DL-Alpha-lipoic Acid / Thioctic acid; I-Liposan; Lipothion; I-NSC 628502; I-NSC 90788; I-Protogen A; I-Thioctsan;
Formula Yamamolekhula	C8H14O2S2
isisindo Yamamolekhula	206.318 g / mol
I-Melting Point	60-62 ° C
InChI Key	Ingxenye #: AGBQKNBQESQNJD-UHFFFAOYSA-N
Ifomu	Solid
ukubukeka	Kukhanya Okuphuzi Kaphuzi
Ukuphila okungaphelele	Imizuzu engama-30 ukuya ehoreni eli-1
solubility	I-soluble ku-Chloroform (kancane), i-DMSO (kancane), iMethololi (kancane)
isitoreji Isimo	Okomile, okumnyama naku-0 - 4 C isikhathi esifushane (izinsuku kuya emavikini) noma -20 C isikhathi eside (izinyanga kuya eminyakeni).
Isicelo	Isikhuthazi se-fat-metabolism.
Idokhumenti yokuhlola	Iyatholakala
I-Alpha-lipoic Acid Isithombe sempushana

Yini i-Alpha-lipoic Acid?

I-Alpha-lipoic acid iyi-antioxidant etholakala ku-caprylic acid. Amanye amagama alo yi-ALA, lipoic acid, Biletan, Lipoicin, Thioctan, njll. Igama layo lamakhemikhali lingu-1,2-dithiolane-3-pentanoic acid noma i-thioctic acid. Kuyinhlanganisela ye-organosulfur futhi ikhiqizwa emzimbeni wabantu nasezilwaneni. Ukukhiqizwa kwayo kwenzeka kusuka ku-octanoic acid kanye ne-cysteine ​​njengomthombo wesibabule. Kuyinto ebalulekile yomzimba we-aerobic emzimbeni. Itholakala kuwo wonke amaseli futhi isiza ukudala amandla kusuka ku-glucose.

Inemisebenzi eminingi yeselula neyemangqamuzana, ngenxa yamakhono ayo e-antioxidant. Lesi senzo sokulwa ne-alpha-lipoic acid sikhulise intshisekelo yaso yokusetshenziswa njengesengezo sokudla okunempilo. Ibuye isetshenziswe njenge-agent yokwelapha. Kungaba ukwelashwa kwesifo sikashukela, ukwehla kwesisindo, i-neuropathy okubangelwe yisifo sikashukela, ukuphulukiswa kwesilonda, ukwenza ngcono izimo zesikhumba, njll.

I-alpha-lipoic acid powder ine-half-life yemizuzu engama-30 kuya ehoreni elilodwa. Iyancibilika kancane ku-chloroform, dimethyl sulfoxide (DMSO), ne-methanol. Ingatholakala kusipinashi, imvubelo, i-broccoli, amazambane, inyama efana nesibindi nezinso.

Umthamo omkhulu umuntu omdala ongawuthatha ngosuku ngu-2400mg.

Isebenza kanjani i-Alpha-lipoic Acid?

I-Alpha-lipoic acid inezakhiwo zokulwa ne-antioxidant. Kusho ukuthi ingalwa ngokuqinile nama-radicals mahhala emzimbeni futhi yehlise ijubane ezehlakalweni ezinjengokuguga kwamaseli futhi isize ukugcina amaseli aphilile.

Ikhiqizwa kwi-mitochondria futhi isebenza njenge-cofactor ebalulekile yokwephula ama-enzyme nezakhi zomzimba. Iphinda ithuthukise i-ayoni yensimbi futhi inciphise ifomu elenziwe oxidized lamanye ama-antioxidants afana novithamini C, Vitamin E, kanye ne-glutathione. I-alpha-lipoic acid iyadingeka ekulawuleni izinhlobo ze-oxygen ezisebenzayo.

I-Alpha-lipoic acid futhi iphakamisa uhlelo lokuvikela i-antioxidant. Lokhu ikwenza nge-Nrf-2-mediated antioxidant expression expression. Iphinde iguqule izakhi zofuzo ezidinga i-peroxisome proliferator ukuze isebenze.

I-Alpha-lipoic acid futhi ivimbela i-nuclear factor kappa B. Isebenzisa i-AMP-activated protein kinase (AMPK) emisipheni yamathambo futhi ibangele nezenzo ezahlukahlukene zomzimba.

Kunezinhlobo ezimbili ze-alpha-lipoic acid. Zine-lipoic acid (LA) ene-oxidized futhi inciphise i-dihydrolipoic acid (i-DHLA). I-DHLA ikhiqizwa kwimitochondria equkethe amaseli emzimbeni. Lokhu kungenzeka nge-nicotinamide adenine dinucleotide hydrogen (NADH) ne-lipoamide dehydrogenase. Lezi zinto ezimbili zisiza kulokhu kuphendula kokuguqula.

Kumaseli angenayo i-mitochondria, i-alpha-lipoic acid ingancishiselwa ku-DHLA nge-nicotinamide adenine dinucleotide phosphate (NADPH). Lesi senzo sisizwa yi-glutathione ne-thioredoxin reductases.

I-Alpha-lipoic acid inempahla eyingqayizivele eyenza ihluke ku-glutathione. Ngenkathi kuphela ifomu elehlisiwe le-glutathione eline-antioxidant, zombili izinhlobo ezincishisiwe nezingancishisiwe ze-alpha-lipoic acid zingama-antioxidants anamandla.

I-Alpha-lipoic acid nayo ibandakanyekile ekulungiseni amaprotheni ane-oxidized futhi ingasiza ekulawulweni kokubhalwa kofuzo.

I-Alpha-lipoic acid inezakhiwo ezilwa nokuvuvukala futhi. Imisa i-kappa B kinase, i-enzyme eyenza kusebenze i-NF-kB, into eyenza ukuthi i-cytokines yokuvuvukala [1] isebenze.

Umlando we-Alpha-lipoic Acid

I-alpha-lipoic acid yatholwa ngo-1937 nguSnell. Ngaleso sikhathi, ososayensi babefunda ngohlobo lwebhaktheriya elalisebenzisa ujusi wamazambane ukukhiqiza. 1n 1951, yahlukaniswa nguMhlanga. Ukusetshenziswa kokuqala kwemitholampilo kwaqala eJalimane ngo-1959 ekwelapheni ubuthi ngenxa yamakhowe ekhanda lokufa.

Imininingwane ephathelene nokusetshenziswa kwe-alpha-lipoic acid nokusebenza kwayo ayikaqedwa. Ukusetshenziswa kwayo ekwelashweni akukakaqinisekiswa yi-FDA okwamanje. Kepha eminyakeni edlule, ithole ukuthandwa njengesengezo.

Yini Imiphumela Emibi ye-Alpha-lipoic Acid?

Njengeminye imithi eminingi, i-alpha-lipoic acid nayo inemiphumela engemihle.

Eminye yemiphumela emibi kakhulu ye-alpha-lipoic acid yile:

• bekhanda
• isilungulela
• I-nausea
• Ukuvota
• Hypersensitivity
• Ukukhanya okukhanyayo
• Ushukela ophansi wegazi
• Ukukhwabanisa isikhumba
• I-Intoxication

Imiphumela ye-Alpha-lipoic acid powder komama abakhulelwe nabancelisayo ayaziwa. Ngakho-ke kunconywa ukuthi ugweme ukusebenzisa lokhu lapho ukhulelwe noma uncelisa.

Ziyini Izinzuzo Ze-Alpha-lipoic Acid?

Kunezinzuzo eziningana ze-alpha-lipoic acid. Kunjalo:

Umphumela Esifo Se-Alzheimer's

I-alpha-lipoic acid powder inamandla okubambezela ukuqala noma ukunciphisa ijubane ukuqhubeka kwesifo se-neurodegenerative. Kwenziwa ucwaningo ezigulini eziyisishiyagalolunye ezinesifo i-Alzheimer's. I-600mg ye-Alpha-lipoic acid yanikezwa nsuku zonke izinyanga eziyi-12 [2]. Ibikwazi ukuzinzisa ukuqonda kulezi ziguli. Impahla yayo ye-antioxidant ingahle yehle ngesimo futhi ingasebenza njenge-ejenti yokuvikela izinzwa.

Umphumela Wesifo Sikashukela

I-Alpha-lipoic acid ingasiza ekwehliseni amazinga kashukela egazini ezigulini ezinesifo sikashukela. Njengoba izakhiwo zayo zokulwa ne-antioxidant zingasusa ama-radicals mahhala emzimbeni, zingasiza ekwelapheni umonakalo kumaseli abangelwa yisifo sikashukela. Kungabuye kuthuthukise ukumelana ne-insulin kubantu abanesifo sikashukela. Kungavimbela ukufa kwamaseli we-beta futhi kungahle kuthuthukise ukuthathwa kweglucose futhi kubambezele phansi izinkinga zesifo sikashukela, ikakhulukazi isifo sikashukela sokuzwela ngemizwa [3].

Umphumela ku-Stroke

I-Alpha-lipoic acid inamakhono we-neuroprotective. Izenzo zayo zokulwa ne-antioxidant zingasiza futhi ekwandeni kwe-neuron ebuchosheni obuhlaselwe yisifo sohlangothi. Ucwaningo olwenziwe kumagundane ane-ischemic stroke abanikezwe i-alpha-lipoic acid lukhombise ukuthuthuka esimweni sabo [4]. Ngakho-ke, kungasiza ukuthuthukisa isimo seziguli ezinesifo sohlangothi.

Umphumela Ekugugeni

I-alpha-lipoic acid powder nayo ingakwazi ukusiza ukwehlisa ukuguga kwesikhumba. I-Alpha-lipoic acid inganikeza i-electron eyodwa kwisithako esisebenzayo esilimaza isikhumba futhi sigugise futhi izenze i-oxidize uqobo. Ngale ndlela ingayeka ukuguga futhi ingagcwalisa nendima yengxenye ye-antioxidant entekenteke [5]. Lokhu kungasiza ekulweni nomonakalo odalwe yizinto ezahlukahlukene.

Umphumela Wobuthi beMercury ne-Autism

I-Alpha-lipoic acid ingadlula isithiyo segazi nobuchopho. Kungasetshenziselwa ngisho nokukhipha ubuthi i-mercury enamathiselwe kumaseli obuchopho uma kwenzeka kunobuthi be-mercury [6]. Ingakwazi ukuhlanganisa i-mercury eboshiwe iye egazini kusuka lapho amanye ama-chelator agents afana ne-dimercaptosuccinic acid (DMSA) noma i-methylsulfonylmethane (MSM) angadlulisela i-mercury ngokuphepha ezinso bese ekhishwa emchameni. Njengoba i-DMSA noma i-MSM ingeqi isithiyo segazi nobuchopho, ukusebenzisa i-alpha-lipoic acid ene-DMSA kungasiza ukususa ngokuphepha i-mercury. Lokhu kungasiza ekwelapheni i-autism njengezingane ze-autistic ezinamazinga aphezulu e-mercury ebuchosheni bazo uma kuqhathaniswa nokujwayelekile. Kodwa-ke, izifundo eziphathelene nalokhu zikhawulelwe.

Umphumela ku-Anemia

Kwenziwa ucwaningo ezigulini ezinesifo sezinso sokugcina esine-anemia lapho i-alpha-lipoic acid yanikezwa iziguli [7]. Ikhombise ukuthi inekhono njenge-erythropoietin ekwandiseni amazinga e-hemoglobin ngaphandle kwemiphumela emibi. Ngakho-ke, kungasiza ekwelapheni i-anemia okubangelwa ukwehluleka kwezinso zokugcina. Kungasizakala nangokwezomnotho.

Umphumela njenge-Antioxidant

Njengoba i-alpha-lipoic acid powder iyi-antioxidant, inezinzuzo eziningi futhi ingasiza ngezinhlobo eziningi zezimo emzimbeni.

Umphumela ku-Neurotoxicity Ngenxa Yotshwala

Utshwala bungadala ukuphazamiseka kwemizwa ngenxa yengcindezi ene-oxidative. I-Alpha-lipoic acid ingasiza ekwelapheni i-neurotoxicity ngenxa yotshwala. Kungavimbela i-protein oxidation eyenzeka ekudleni kwe-ethanol [8].

Umphumela Wokulahlekelwa Isisindo

I-Alpha-lipoic acid ingabuye ibe isengezo esihle sokusiza ekwehliseni isisindo sabantu abakhuluphele ngokweqile nabakhuluphele ngokweqile [9]. Inemiphumela engemihle uma iqhathaniswa neminye imithi yokwehlisa isisindo futhi inama-antioxidants angasiza ekugcineni umuntu enempilo.

Izimo

Azikho izifundo eziningi eziphikisanayo ze-alpha-lipoic acid. Kodwa-ke, ezinye iziguli ezinezimo ezithile kufanele ziqaphele ngaphambi kokusebenzisa le nto futhi zibonane nodokotela ngaphambi kokuyisebenzisa.

Ezinye zalezi zimo yilezi:

• Isifo sesibindi
• Ukuphuza utshwala ngokweqile
• Isifo sendlala yegilo
• Ukushoda kwethayamine

Ukusebenzisana Kwezidakamizwa Ne-Alpha-lipoic Acid

Akukho lwazi oluningi ngokuxhumana kwe-alpha-lipoic acid nezinye izidakamizwa. Kepha eminye imithi kungcono ukugwenywa ngalesi sengezo.

Eminye yale mithi yile:

Izidakamizwa ze-Hypoglycemic - I-Alpha-lipoic inamandla okuncipha kashukela egazini. Kwezinye izimo kungadala i-insulin autoimmune syndrome, eholele ku-hypoglycemia. Ngakho-ke ukuyisebenzisa ngezidakamizwa ze-hypoglycemic kungadala i-hypoglycemia esheshayo engaba yingozi.

Imithi yegilo - I-Alpha-lipoic acid ingehlisa izinga lamahomoni wegilo. Ngakho-ke ukuqapha okufanele kuyadingeka lapho kusetshenziswa i-levothyroxine.

Ungayitholaphi i-Alpha-lipoic Acid ngo-2021?

Ungathenga i-alpha-lipoic acid powder ngqo kusuka enkampanini ekhiqiza i-alpha-lipoic acid. Itholakala ngomphunga oqinile ophuzi nophuzi ophuzi. Igcwele iphakethe elingu-1 kg iphakethe ngalinye kanye no-25kg ngesigubhu ngasinye. Noma kunjalo, lokhu kungashintshwa ngokuya ngezidingo zomthengi.

Kudinga ukugcinwa ezingeni lokushisa elingu-0 kuye ku-4 ° C esikhathini esifushane no -20 ° C esikhathini eside. Idinga indawo ebandayo, emnyama, futhi eyomile yokugcina ukuze iyivimbele ekusebenzeni namanye amakhemikhali asemvelweni. Lo mkhiqizo wenziwe ngezithako ezinhle kakhulu ezilandela imigomo efanelekile.

Izinkomba Ezibaluliwe

1. Li, G., Fu, J., Zhao, Y., Ji, K., Luan, T., & Zang, B. (2015). I-Alpha-lipoic acid inemiphumela yokulwa nokuvuvukala kumaseli we-lipopolysaccharide-evuselelwe ama-rat mesangial nge-inhibition ye-nuclear factor kappa B (NF-κB) ebonisa indlela. Ukuvuvukala, 38(2), i-510-519.
2. UHager, K., Kenklies, M., McAfoose, J., Engel, J., & Münch, G. (2007). I-α-lipoic acid njengenketho entsha yokwelashwa kwesifo i-Alzheimer's-Ukuhlaziywa kokulandela izinyanga ezingama-48. Ku- Ukuphazamiseka Kwe-Neuropsychiatric Indlela Yokuhlanganisa(amakhasi 189-193). Springer, eVienna.
3. ULaher, I. (2011). Isifo sikashukela kanye ne-alpha-lipoic acid. Frontiers ekhemisi, 2, 69.
4. Choi, KH, Park, MS, Kim, HS, Kim, KT, Kim, HS, Kim, JT,… & Cho, KH (2015). Ukwelashwa kwe-alpha-lipoic acid kuyindlela yokwelapha futhi kukhuthaza ukutakula okusebenzayo ngemuva kokushaywa amagundane. Ubuchopho bamangqamuzana, 8(1), i-1-16.
5. UKim, K., Kim, J., Kim, H., & Sung, GY (2021). Umphumela we-α-Lipoic Acid Ekuthuthukisweni Kwama-Skin Equivalents Wokusebenzisa I-Pumpless Skin-on-a-Chip Model. I-International Journal of Sciences Molecular, 22(4), i-2160.
6. UBjørklund, G., Aaseth, J., Crisponi, G., Rahman, MM, & Chirumbolo, S. (2019). Imininingwane ye-alpha-lipoic ne-dihydrolipoic acid njengezethembisi ezithembisayo zokuxineka kwe-oxidative kanye nama-chelators okungenzeka abe khona kwi-mercury toxicology. Ijenali yamakhemikhali ezinto ezingaphili, 195, I-111-119.
7. I-El-Nakib, GA, Mostafa, TM, Abbas, TM, El-Shishtawy, MM, Mabrouk, MM, & Sobh, MA (2013). Indima ye-alpha-lipoic acid ekuphathweni kwe-anemia ezigulini ezinokuhluleka kwezinso okungamahlalakhona okwenziwa i-hemodialysis. Ijenali yomhlaba wonke ye-nephrology kanye nesifo sokuvuselela, 6, 161.
8. UPirlich, M., Kiok, K., Sandig, G., Lochs, H., & Grune, T. (2002). I-Alpha-lipoic acid ivimbela i-ethanol-induced protein oxidation kumaseli we-hippocampal HT22 amaseli. Izincwadi Ze-Neuroscience, 328(2), i-93-96.
9. UKucukgoncu, S., Zhou, E., Lucas, KB, & Tek, C. (2017). I-Alpha ‐ lipoic acid (ALA) njengesengezo sokuncipha kwesisindo: imiphumela evela ekuhlaziyweni kwe-meta-kwezivivinyo ezilawulwa ngokungahleliwe. Ukubuyekezwa kokukhuluphala, 18(5), i-594-601.

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