Imikhiqizo

I-Pterostilbene powder (537-42-8)

I-Pterostilbene yi-stilbenoid ngamakhemikhali ehlobene ne-resveratrol. Kungokweqembu lama-phytoalexins, ama-ejenti akhiqizwa izitshalo ukulwa nezifo.Ngokusekelwe ocwaningweni lwezilwane kucatshangwa ukuthi kukhombisa anti-umdlavuza, izindawo ezilwa ne-hypertcholesterolemia, izakhiwo ze-anti-hypertriglyceridemia, kanye nekhono lokulwa nokubuyela emuva kokuncipha kwengqondo . Kukholakala ukuthi i-compound nayo inezinto ezilwa nesifo sikashukela, kepha kuze kube manje kuncane kakhulu okufundiwe.

Ukwakha: Ukukhiqizwa Kweqoqwana
Iphakheji: 1KG / isikhwama, 25KG / isigubhu
I-Wisepowder inamandla okukhiqiza nokuhlinzeka ngobuningi obukhulu. Konke ukukhiqizwa ngaphansi kwesimo se-cGMP kanye nohlelo oluqinile lokulawula ikhwalithi, yonke imibhalo yokuhlola nesampula etholakalayo.

1.Yini iPterostilbene?

2.Iyini i-Pterostilbene powder?

3.Iyini indlela yokusebenza ye-Pterostilbene?

4.Iyini i-Pterostilbeneuse?

5.Iziphi izinzuzo zokuthatha i-Pterostilbene?

6.Iziphi izinzuzo ze-Pterostilbene esikhumbeni?

7.Ingabe i-Pterostilbene ilungele ubuchopho?

8.Ingabe i-Pterostilbene inhle ekunciphiseni isisindo

9.Pterostilbenefits ekukhuleni kwezinwele

10.Umthamo we-Pterostilbene

11.Pterostilbene side effects

12.Pterostilbene yokukhathazeka

13.Pterostilbene yokuzala

14.Pterostilbene yezinja

15.Yikuphi ukudla okuqukethe i-Pterostilbene?

16.Ithathwe kuphi i-Pterostil?

17.Imithombo ye-Pterostilbenenatural

18.Ingabe i-Pterostilbene iyi-phytoestrogen

19.Ingabe amafutha e-Pterostilbene ayancibilika

20.Ingabe i-Pterostilbene amanzi ayancibilika?

21.Ngabe i-Pterostilbene iyayenyusa i-LDL?

22.Ingabe i-Pterostilbenelowder blood pressure?

23.Ingabe i-Pterostilbene iyingozi

24.Ingakanani i-Pterostilbene okufanele ngiyithathe?

25.Pterostilbenewith noma ngaphandle kokudla?

26.Ingabe kufanele uthathe i-Pterostilbene?

27.Isiphi isikhathi esingcono kakhulu sosuku sokuthatha i-Pterostilbene?

28.Iziphi izithasiselo eziqukethe i-Pterostilbene?

29.Ingabe i-Pterostilbene ingcono kune-Resveratrol?

30.Ubani okungafanele aphuze i-resveratrol

31.Ingakanani i-resveratrol ephephile?

32.Pterostilbene ne-caffeine

33.I-Pterostilbene ene-quercetin

34.Pterostilbene vs berberine

35.Pterostilbene kanye ne-NMN

36.Pterostilbene kanye ne-Nicotinamide riboside

37.Ungayithenga kuphi i-Pterostilbene?

 

I-Pterostilbene powder (537-42-8) ividiyo

 

I-Pterostilbene kuthiwa ingcono kune-resveratrol. Bayibiza ngegazi likadrako, noma umthombo wobusha. Uyafuna ukwazi okwengeziwe nge-Pterostilbene? Nazi 37 FAQ odinga ukuyazi:

 

1. Yini i-Pterostilbene?

I-Pterostilbene (trans-3,5-dimethoxy-4-hydroxystilbene) iyi-polyphenol eyenzeka ngokwemvelo, uhlobo lwe-molecule eyenzeka ezitshalweni. Iyingxenye yeqembu le-stilbene lama-compounds kanye nengxenye eyinhloko ye-antioxidant yama-blueberries. Ezitshalweni, isebenza indima evikelayo ye-antimicrobial kanye ne-antioxidative.

I-Pterostilbene yatholwa okokuqala ngo-1977 nguLangcake noPryce futhi iye yafundelwa izakhiwo zayo ze-antioxidant kanye nezinzuzo zezempilo ezingaba khona.

I-Pterostilbene ihlobene ngamakhemikhali ne-resveratrol, esinye isengezo sokudla esidumile; ezinye izifundo ziphakamisa ukuthi ingaba usizo kakhulu empilweni kunobudlelwane bayo obuseduze, ngezinye izikhathi iphakamisa isiphakamiso sokuthi ingase ibe "i-resveratrol engcono".

 

Izinzuzo eziyinhloko ze-Pterostilbene zingafingqwa ngale ndlela elandelayo:

1 I-Pterostilbene iyinto yemvelo etholakala ngamanani amancane emifino nezithelo ezinjengama-blueberries.
2 I-Pterostilbene i-molecule encane engcono kune-resveratrol mayelana nokumuncwa nokuzinza.
3 I-Pterostilbene yandisa isikhathi sokuphila ezintweni ezihlukahlukene.
4 I-Pterostilbene inganciphisa ukuvuvukala.
5 I-Pterostilbene ingathuthukisa ukulungiswa kwe-DNA.
6 I-Pterostilbene ingenza kusebenze ama-sirtuin, okungama-enzyme alungisa i-DNA, athuthukise imetabolism futhi anganweba ubude bempilo nempilo.
7 I-Pterostilbene ingathuthukisa ukusebenza kobuchopho futhi ingavikela ubuchopho.
8 I-Pterostilbene inganciphisa ukuqoqwa kwamaprotheni, okungenye yezinto ezibangela ukuguga.
9 I-Pterostilbene yenza i-AMPK isebenze, i-enzyme ebalulekile engavikela amaseli ekugugeni.
10 10. I-Pterostilbene inyusa ukukhiqizwa kwama-enzyme anamandla e-antioxidant, ivikela amaseli emonakalweni we-oxidative.

 

2. Iyini i-Pterostilbene powder? 

I-Pterostilbene powder iyimpahla eluhlaza ye-Pterostilbene enombala omhlophe.

 

I-Pterostilbene powder (537-42-8) Ulwazi Lwesisekelo

Igama I-Pterostilbene powder
CAS inombolo 537-42-8
Ukuhlanzeka 98%
Igama lamakhemikhali I-Pterostilbene (I-Dimethylresveratrol)
omqondofana I-3,5-Dimethoxy-4-stilbenol, 3,5-Dimethoxy-4-hydroxy-E-stilbene
Formula Yamamolekhula C16H16O3
isisindo Yamamolekhula I-256.3 g / mol
I-Melting Point I-89-92 ° C
InChI Key I-VLEUZFDZJKSGMX-ONEGZZNKSA-N
Ifomu powder emhlophe
Ukuphila okungaphelele solubility
isitoreji Isimo vikela ekukhanyeni, 2-8 ° C
Isicelo Ukusebenza kwangaphambili, izithasiselo zokwakha umzimba, izimonyo
I-COA,HPLC Iyatholakala
I-Pterostilbene

powder

I-Pterostilbene-imikhiqizo02

 

 

3. Iyini indlela yokusebenza ye-Pterostilbene?

I-Pterostilbene iyi-polyphenol, uhlobo lwe-molecule eyenzeka ezitshalweni, ikakhulukazi amajikijolo amancane namantongomane. Ama-Blueberries angumthombo ocebile we-pterostilbene; yize itholakala kumagilebhisi, i-pterostilbene (ngokungafani nomzala wayo we-resveratrol) ayiphili inqubo yokwenza iwayini.

Yini polyphenol? Igama elithi “Phenol” lisho isakhiwo esithile samakhemikhali (kulokhu, iqembu le-hydroxyl elixhunywe kwindandatho ye-benzene); Igama elithi “poly” lisho nje ukuthi ama-molecule aqukethe ngaphezu kwesakhiwo esisodwa. Omunye wemisebenzi eyinhloko ye-polyphenols ukusiza isitshalo ukulwa namagciwane. Lapho kudliwa ngabantu, ama-polyphenols angasebenza njengama-antioxidants anamandla.

Ososayensi bebelokhu bezazi iziphithiphithi kusukela ekuqaleni kwekhulu le-19 leminyaka - uJoseph Lister, oyiphayona lokuhlinzwa kwe-antiseptic, wabika ngesimo esisodwa sezibulala-magciwane ngo-1867 - yize igama elithi "polyphenol" lalingazange lisebenzise ukusetshenziswa kwalo okokuqala kuze kube ngu-1894.

Njengawo wonke ama-polyphenols, abacwaningi abaqondi kahle ukuthi i-pterostilbene isebenza kanjani. UDkt. esinakho. ”

 

I-4. Kuyini I-Pterostilbene sebenzisa for?

I-Pterostilbene ingasiza ekuvikeleni isifo se-Alzheimer kanye nokuncipha kwengqondo okuhlobene nokuguga, ngokusho kocwaningo olusekelwe ezilwaneni olwanyatheliswa kuyi-Neurobiology of Aging ngo-2012. Ekuhlolweni kwamagundane, ababhali bocwaningo banqume ukuthi i-pterostilbene ingasiza ekulondolozeni umsebenzi wokuqonda, ngokwengxenye ngokunciphisa. ukuvuvukala.

 

5. Yiziphi izinzuzo zokuthatha i-Pterostilbene?

Izinzuzo eziningi ze-pterostilbene ekwelapheni nasekuvimbeleni izifo zabantu ziye zabangelwa izakhiwo zayo ze-antioxidant, anti-inflammatory, kanye ne-anticarcinogenic eziholela ekusebenzeni okuthuthukisiwe kwamangqamuzana avamile kanye nokuvinjelwa kwamaseli ayingozi.

Ucwaningo oluhlukahlukene luye lwabonisa izakhiwo ze-pterostilbene ze-antioxidant, anti-inflammatory, kanye ne-anticarcinogenic, okuye kwaholela ekusebenzeni okuthuthukisiwe kwamangqamuzana anempilo kanye nokuvinjelwa kwamangqamuzana ayingozi.

 

1) Izinzuzo ze-Pterostilbene empilweni yenhliziyo

I-Pterostilbene iye yathinteka empilweni yenhliziyo. ngocwaningo oluthile olubonisa ukuthi lunomphumela ovikelayo ku-atherosclerosis futhi olunye lubonisa ukuthi luthuthukisa izici ze-autophagy futhi lusiza ekulweni nomphumela we-pro-atherosclerosis we-oxidized low-density lipoprotein kumaseli e-vascular endothelial. Iphinde yabonisa usizo olungaba khona ekwelapheni ukulimala kwe-ischemia-reperfusion.

 

2) Izinzuzo ze-Pterostilbene ku Isifo i-Alzheimer

Ucwaningo luphinde lwakhombisa amandla e-pterostilbene maqondana nezimo ze-neurodeergenerative njengesifo i-Alzheimer's. Ucwaningo lwamagundane anokuguga okusheshayo lubonise ukuthi i-pterostilbene, ngisho nangemithamo ephansi, inomthelela omkhulu ekuthuthukiseni ikhono lengqondo.

 

3) I-Pterostilbene ingase ithuthukise ukuqonda

Olunye ucwaningo luphakamisa ukuthi i-pterostilbene ibandakanyeka ku-neural plasticity kanye nokusebenza kwayo okuhlobene kwengqondo nokusebenza kwemoto nokuthi amagundane anikezwe i-pterostilbene enza kangcono ekuhlolweni kwengqondo.

 

4) I-Pterostilbene iyi-anti-inflammatory enamandla

I-Pterostilbene iyi-anti-inflammatory enamandla futhi ingacindezela i-NF-Kb, iphrotheni eyinkimbinkimbi elawula ukulotshwa kwe-DNA, ukukhiqizwa kwe-cytokine kanye nokusinda kweseli. Ucwaningo lwakamuva lubonise ukuthi i-pterostilbene ingakwazi ukwelapha i-pancreatitis eyingozi kakhulu ngokunciphisa amazinga e-serum okuvuvukala kwe-TNF-a, IL-1b, ne-NF-kB nokuthi yehlisa ukukhiqizwa kwezinhlobo ze-oxygen esebenzayo.

I-Pterostilbene futhi inedatha ethile ephakamisa ukuthi ingaba usizo ekwelapheni isifo samathambo, futhi uma kubhekwa izakhiwo zayo zokulwa nokuvuvukala, lokhu akumangazi neze. Nakuba ucwaningo lunqunyelwe kuze kube yimanje mayelana nesifo samathambo, ucwaningo lwamagundane luphakamise ukuthi kungenzeka yini ukwelapha lesi simo.

 

5) I-Pterostilbene ingasiza ukulahlekelwa isisindo

Ucwaningo lwakamuva olwenziwe ezigulini ezine-hypercholesterolemia, ezingayiphuzi imishanguzo yokulwa ne-cholesterol, zithole ukuthi lapho zengezwa ngePterostilbene, lezi zihloko zokuhlola zikhombise inani elikhulu lokwehlisa isisindo. Lokhu kukhomba enzuzweni engaba khona yokuncipha kwesisindo samakhemikhali.

Olunye ucwaningo olwenziwe kumamodeli ezilwane angezwe nge-Pterostilbene powder lubonise ukwanda okukhulu kwenani labantu base-Akkermansia muciniphila emathunjini ezilwane. Ukubaluleka kwalolu hlobo ukuthi kunciphisa ingozi yokukhuluphala, futhi kuthuthukisa impilo yonke yamathumbu.

 

6) I-Pterostilbene ithuthukisa ukusebenza kwenhliziyo

Izici ze-antioxidant zePterostilbene zisiza kakhulu enhliziyweni, njengoba zinciphisa ukucindezeleka okwenziwe nge-oxidative esithweni. Izifundo ezinhlobonhlobo zezilwane zikhombise ukwehla okukhulu kwenhliziyo yamaphaphu, okubangelwa yingcindezi enhliziyweni ngokungasebenzi kwamaphaphu.

 

7) I-Pterostilbene ivikela izici ekuboneni

Njengamanje, kunezifundo ezimbalwa ezigxile ekhonweni lale polyphenol ekwehliseni izehlakalo zobumpumputhe ezigulini ezinesifo sikashukela. Isidingo salolu cwaningo saphakanyiswa njengomphumela wesinye isifundo esifakazela ukuthi iPterostilbene inciphisa ukuvuvukala ku-cornea. Lokhu kutholakala kuholele ekutheni abacwaningi baphokophele ukusetshenziswa kwePterostilbene powder ekwelapheni iso elomile.

 

6. Yiziphi izinzuzo ze-Pterostilbene esikhumbeni?

Ukhilimu we-Pterostilbene oqukethe i-Pterostilbene powder ubusebenza kahle kakhulu ekwehliseni izimpawu zokuguga futhi unxenxa ithoni yesikhumba. Umkhiqizo ubusebenza ngempumelelo ekwehliseni imibimbi nemigqa emihle, uthuthukise ukunwebeka kwesikhumba futhi ukhombise imiphumela emibi.

 

7. Ingabe i-Pterostilbene ilungele ubuchopho? 

Yebo, i-Pterostilbene ilungele ubuchopho. I-Pterostilbene ingathuthukisa ukusebenza kobuchopho futhi ingavikela ubuchopho. I-Pterostilbene inganciphisa ukuqoqwa kwamaprotheni, okungenye yezinto ezibangela ukuguga. I-Pterostilbene yenza i-AMPK isebenze, i-enzyme ebalulekile engavikela amaseli ekugugeni.

 

8. Ingabe i-Pterostilbene inhle ekunciphiseni isisindo

I-Pterostilbene ikhiqize imiphumela emihle yokuncipha kwesisindo okungenani ocwaningweni olulodwa, kodwa izifundo ezinkulu neziqinile ziyadingeka ukuze kuqinisekiswe ukusebenza kwayo.

Ocwaningweni lwabantu abaneminyaka ephakathi abane-cholesterol ephezulu, labo ababengayisebenzisi imithi ye-cholesterol balahlekelwa isisindo esincane, kodwa esibalulekile, kuyilapho befaka i-pterostilbene. Lo mphumela wawumangalisa ngandlela-thile, njengoba lolu cwaningo lwalungaklanyelwe ukukala i-pterostilbene njengosizo lokulahlekelwa isisindo. Lo mphumela awukakaphenywa ocwaningweni oluhlukile.

Ucwaningo lwamaseli nezilwane luphinde luphakamise ukuthi i-pterostilbene ingasiza ekuthuthukiseni ukuzwela kwe-insulin. I-Pterostilbene ivimba ukuguqulwa kukashukela ube amafutha futhi ivimbela amangqamuzana amafutha ukuthi angaphindaphindeki.

I-Pterostilbene ingase futhi iguqule ukwakheka kwezitshalo zamathumbu, amakoloni amagciwane ahlala emathunjini futhi asize ukugaya ukudla.

Amagundane adla i-pterostilbene ayenezitshalo zamathumbu ezinempilo, okuhlanganisa ukwanda okukhulu kwe-Akkermansia muciniphila, uhlobo lwebhaktheriya elibonakala livimbela ukukhuluphala, isifo sikashukela, nokuvuvukala kwezinga eliphansi. I-A. muciniphila muva nje isigxile kakhulu ocwaningweni lwe-probiotic; izifundo zesikhathi esizayo zizocacisa ukuthi i-pterostilbene ikusekela kanjani ukukhula kwayo.

 

9. I-Pterostilbene izinzuzo zokukhula kwezinwele

Ukudla okunempilo, okunomsoco kuyisihluthulelo sekhanda elinempilo lezinwele. Ukugcwalisa ukudla okunothe ngamaprotheni namavithamini kuzosiza ukuthuthukisa ukubukeka kwesikhumba sakho futhi kuthuthukise impilo yakho iyonke, futhi vele, gcina iso nge-resveratrol noma i-Pterostilbene. Uma kungukulahlekelwa izinwele ogxile kukho njengamanje, ungase ufune ukwethula izithasiselo ohlelweni lwakho. Isengezo esihlanganisa amaminerali namavithamini ondla isikhumba sekhanda futhi asize ukusekela izinwele ezibukeka zinempilo.

 

Nazi ezinye izinto ongayenza ukuze unakekele wena nezinwele zakho:

- I-scalp massage

I-massage enhle ye-scalp ingasiza ukukhulula ukungezwani ezungeze umqhele wekhanda, futhi akugcini nje ukuthi uzizwe ulungile, ucwaningo lubonisa ukuthi uma ukwenza njalo, ungase ube nezinwele ezinde. Kuhle, uma ulwa ne-alopecia, ukubhucungwa kwesikhumba kugxile embotsheni yezinwele, etholakala ngaphansi nje kwesikhumba. Lapho lezi follicle zikhuthazwa, imithambo yegazi iyavuleka futhi ukukhula kwezinwele (okungenzeka) kwenzeka.

Hlanza isikhumba sakho izikhathi ezimbalwa ngeviki eshaweni ukuze usize ukukhulisa ukubukeka kwezinwele zakho futhi ukusize ukhululeke. Noma isebenzise ukuze isebenze ku-serum yezinwele zakho eziyintandokazi noma igwebu ukusiza ukusabalalisa umkhiqizo nokusiza ngokumuncwa nokugeleza kwegazi.

 

-Yehlisa Ingcindezi.

Umhlaba ungaba indawo enzima, futhi ngeshwa, uma uzithola ungaphansi kwenani elikhulu lokucindezeleka, ungase futhi ubone ukuqothuka kwezinwele okuningi kunokuvamile. (Sengathi izinto azikhohlisi ngokwanele!) Izingcindezi ziza ngazo zonke izinhlobo nobukhulu - mhlawumbe ubhekene nezimo ezinzima zokusebenza, noma mhlawumbe uphila nezinkinga zezimali. Noma ngabe kuyini, uma ungasitholi isikhathi sokuphumuza kahle, ungase ube nemiphumela engemihle yomzimba.

I-telogen effluvium wuhlobo lokulahlekelwa izinwele okuhambisana kakhulu nokucindezeleka. Ungase futhi ube ne-Alopecia areata (ukuqothuka kwezinwele ezindaweni ezithile), i-Trichotillomania (ukudonsa izinwele) kanye ne-Androgenic alopecia (ukuncipha kwezinwele). Qinisekisa ukuthi udla kahle futhi usebenza ngokuhlanzeka kokulala kwakho ukuze ukhuthaze isimo sokugeleza nokuphumula okujulile.

 

10. Umthamo we-Pterostilbene

Ukwengezwa kwe-pterostilbene ngenjongo yokusiza i-glucose kanye ne-lipid metabolism kuvame ukuba cishe ku-20- 40mg/kg ukungeniswa ngomlomo kumagundane, okuyibanga elilinganiselwe lemithamo yomuntu:

215-430mg womuntu ongu-150lb

290-580mg womuntu ongu-200lb

365-730mg womuntu ongu-250lb

 

Izici ezingenzeka ze-anxiolytic ze-pterostilbene zibonwa ku-1-2mg/kg kumagundane, okuyisilinganiso somuntu esilinganiselwe:

5.5-11mg womuntu ongu-150lb

7.3-14.5mg womuntu ongu-200lb

9-18mg womuntu ongu-250lb

Okuphawuleka ngokuthi i-5-10mg/kg kulawa amagundane (okungaphezu kancane komthamo ophindwe kabili) yehlulekile ukuba nemiphumela efanayo ye-anxiolytic, iphakamisa i-bell-curve engase ithande imithamo ephansi efana netholakala ekusetshenzisweni kokudla esikhundleni semithamo ephezulu evela. ukwesekwa.

Ucwaningo lwabantu olulinganiselwe lusebenzise ama-50mg kabili ngosuku noma ama-125mg kabili ngosuku, futhi ukufakwa kwembewu yamagilebhisi (100mg ngazo zombili izikhathi zomthamo) ngomthamo ophansi kungase kwehlise eminye imiphumela emibi ku-cholesterol ebonwa nge-pterostilbene yodwa.

 

11. Pterostilbene side effects

Uma kuqhathaniswa nemithi enqunyelwe ukwelapha izimpawu ezifana ne-cholesterol ephezulu nezinye izinkinga zempilo ezivamile, i-pterostilbene mancane kakhulu amathuba okuba ibangele imiphumela emibi (njengobuhlungu bemisipha kanye nesicanucanu). Ngokuvamile kuphephile ukusetshenziswa kukho kokubili ukudla nezithako ezingeziwe, kodwa ngemithamo ephezulu kungase kuphazamise imiphumela yemithi ethile.

Uma uthatha imishanguzo ukusiza ukulawula i-cholesterol yakho, umfutho wegazi kanye/noma amazinga kashukela egazini, kungcono ukuthi ukhulume nodokotela wakho kuqala ngaphambi kokuqala noma yiziphi izithasiselo ezintsha. Udokotela wakho angasiza ukuqapha ukusabela kwakho uma ukhetha ukuqala ukuthatha i-pterostilbene ukuze aqinisekise ukuthi umthamo wakho awudingi ukulungiswa.

Noma ithathwa ngemithamo ephezulu, i-pterostilbene itholakale ingenabo ubuthi ngokujwayelekile. Kodwa-ke, imithamo ephezulu ibonakala inganikeli izinzuzo ezengeziwe, yingakho kufanele ulandele izincomo zemithamo, futhi ngokocwaningo olwanyatheliswa kuyi-Journal of Toxicology, "amathuba okuba nobuthi angeke akhishwe ngemithamo ephezulu." Yeka ukuthatha izithasiselo ze-pterostilbene uma uhlangabezana nesicanucanu, ama-aches, isifuba noma iziphi izimpawu ezingajwayelekile. Uma unokungezwani nokudla kwe-pterostilbene okufana namajikijolo, amantongomane noma amagilebhisi, kufanele ukugweme ukudla lokhu kudla noma ngabe kuthathwa ngokuthi “kunempilo.”

 

12. I-Pterostilbene yokukhathazeka

I-Pterostilbene iwukukhishwa kwama-blueberries, ngakho-ke isebenza njenge-anti-oxidant eqinile. Ilawula noma isiza ukulinganisela amasignali ezinzwa kanye nekhemistri ku-hippocampus, yona elawula izinkumbulo. I-Pterostilbene isiza ukwaba kabusha imicabango nezinkumbulo njengokuthi “akunangcindezi,” ikwenze uzizwe ukhululeke kakhudlwana. Ungathatha lezi zithako ze-Pterostilbene nsuku zonke.

 

13. I-Pterostilbene yokuzala

Amaqanda omuntu wesifazane enziwa ngenkathi yena esesiswini. Njengoba lawo maqanda ekhula, i-DNA yawo iba ntekenteke futhi ithambekele kakhulu ekulimaleni kwechromosomal. Lo monakalo we-chromosomal uyimbangela ehamba phambili yokulahleka kokukhulelwa kuwo wonke amaqembu eminyaka yobudala, futhi ingozi yokuphuphuma kwesisu iyanda njengoba umuntu ekhula. Iminyaka yobudala iyisici sokuqala esithinta ukuzala kowesifazane.

I-Pterostilbene iyi-antioxidant enamandla ebonwe isiza ngekhwalithi yamaqanda. Kulula kakhulu ukuyithatha futhi ayikaze ibe nombiko wesiguli nganoma yimiphi imiphumela emibi.

I-Resveratrol iyinhlanganisela yemvelo ye-polyphenolic elwa nokuguga, i-antioxidant, elwa nokuvuvukala kanye ne-insulin. Ubufakazi obukhulayo bubonisa ukuthi i-resveratrol inemiphumela yokwelapha engaba khona kwabesifazane abangazali abanokuncipha kokusebenza kwe-ovarian, i-polycystic ovary syndrome (PCOS), noma i-endometriosis.

Ngaphandle kokusebenzisa izithasiselo ze-Pterostilbene noma i-Resveratrol, indlela yokuphila enhle ilungele inzalo futhi. Ngokwesibonelo:

-Sleep

Lapho sifunda okwengeziwe ngokulala, kulapho sithola khona ukuthi amahora ayisishiyagalombili noma ngaphezulu adingeka ubusuku ngabunye ukuze sibe nempilo enhle. Lokhu kuyiqiniso ikakhulukazi emaqandeni ethu. Imizimba yethu yenzelwe ukuthi ivuke nelanga futhi ilale lapho kuhwalala. Ukulala ngokwanele kuyisihluthulelo sokulinganisela kwe-hormonal, okubuye kusekele ukukhula kweqanda elinempilo. Ukulala nakho kudlala indima ebalulekile ekugcineni isisindo esifanele, ukukhuthaza amazinga amahle wamandla, nokunciphisa ingcindezi.

 

-Ukuzivocavoca

Okunye ukuzivocavoca kuhle, kodwa okuningi kungakusebenzela uma ufuna ukukhulelwa. Umzimba unamagiya amabili:

Ukulwa-noma-ndiza

Okuphakelayo nokuzalanisa

Ukuzivocavoca umzimba okukhandlayo kubeka umzimba esimweni sokulwa noma sokundiza. Lokhu kuthinta ama-hormone akho, kucindezela ukukhula kweqanda, futhi kwenza kube nzima ukukhulelwa. Ukuzivocavoca okumaphakathi kuya kokuphakathi, cabanga ukuhamba noma i-yoga ethambile, gcina igazi lakho lizungeza ngenkathi ugcina umzimba wakho ukumodi yokuphakelayo nokuzalanisa.

 

14. I-Pterostilbene yezinja

Qhathanisa nolwazi mayelana ne-Pterostilbene yezinja, ulwazi olwengeziwe mayelana ne-Resveratrol yezinja. Ucwaningo olwenziwa ngo-2015 lwathola ukuthi i-resveratrol inyusa futhi icindezela amasosha omzimba. I-Resveratrol ikhuthaza amangqamuzana egazi amhlophe ukuthi akhulule ama-cytokine abangela ukuvuvukala kunokujwayelekile. Amangqamuzana egazi amhlophe asebenzisa la ma-cytokines ukuze axhumane lapho elwa nezifo. Uma ama-cytokine engeziwe, amasosha omzimba anamandla.

Kodwa-ke, i-resveratrol kanyekanye icindezela amasosha omzimba ngokunciphisa umsebenzi wama-neutrophils. Lawa maseli amhlophe egazi alwa futhi abulale amagciwane ngesikhathi sokutheleleka. Lokhu okutholakele okungqubuzanayo kwenza kube nzima nakakhulu ukunquma ukuthi i-resveratrol iyawasiza ngempela amasosha omzimba.

Inhlanganisela ingase futhi ivimbele umdlavuza, ikakhulukazi umdlavuza wamathumbu kanye nowebele, ngokuvimbela nokunciphisa ukukhula kwamangqamuzana omdlavuza. I-Resveratrol nayo inezakhiwo ze-antihypertensive, futhi ingavimbela umfutho wegazi ophakeme kanye ne-cholesterol. Kuphinde kucatshangwe ukuthi kugqugquzela impilo yezinzwa, nakuba lokhu kungakaqinisekiswa. Ezinye izifundo ziphakamisa ukuthi kungase kwenyuse isikhathi sempilo yesilwane.

Yize lokhu okutholakele kubonakala kuthembisa, odokotela bezilwane basaphenya ngemiphumela egcwele ye-resveratrol kumasosha omzimba we-canine. Akukacaci ukuthi ukusetshenziswa isikhathi eside kwezithako ze-resveratrol kubangela noma yimuphi umonakalo ezinjeni nakwezinye izilwane. Ucwaningo olwengeziwe luyadingeka ukuze kutholwe imiphumela emibi yenhlanganisela, hhayi nje ezinjeni kodwa kuzo zonke izilwane.

Ukwengeza, cishe zonke izifundo eziphakamisa ukuthi i-resveratrol inenzuzo kakhulu yenziwa kumaseli akhulisiwe, izimpukane zezithelo, izinhlanzi, namagundane. Yize ucwaningo lukhombisa ukuthi i-resveratrol inyusa isikhathi sokuphila salezi zilwane, i-resveratrol cishe izothinta izinja ngendlela ehlukile. Kunezifundo ezimbalwa ngemiphumela ye-resveratrol ezinjeni.

Ucwaningo oluningi luhlala lunethemba ngezinzuzo zezempilo ze-resveratrol kokubili ama-canine nakubantu. Nokho, kungase kungabi isengezo esiyisimangaliso eminye imithombo ethi siyiso.

Izinja eziningi ezinempilo ngeke zidinge ukwesekwa kwe-resveratrol, ikakhulukazi njengoba i-resveratrol kufanele inikezwe ngamanani amancane kakhulu. Uma ufuna ukwengeza i-resveratrol eyengeziwe kancane ekudleni kwenja yakho, cabanga ukuyipha amajikijolo aluhlaza noma amantongomane. Kokubili ukudla kuqukethe i-resveratrol eyenzeka ngokwemvelo, ngaphezu kwamavithamini, amaminerali, nama-antioxidants anenhliziyo enempilo.

Ungalokothi unikeze noma yiziphi izithasiselo enjeni yakho ngaphandle uma uyalelwe ngokucacile ukuba yenze kanjalo ngudokotela wezilwane. Uma ukholelwa ukuthi inja yakho ingase izuze esithasiselweni se-resveratrol, buza udokotela wakho wezilwane mayelana nezinzuzo kanye nezinkinga ngaphambi kokuthenga noma yiziphi izithasiselo noma ukushintsha ukudla kwenja yakho. Sebenzisa kuphela izithasiselo ngemithamo enconywe udokotela wakho wezilwane.

 

15. Yikuphi ukudla okuqukethe i-Pterostilbene? 

I-Pterostilbene itholakala kuma-blueberries, ngokuqukethwe okulinganiselwe kwe-blueberry ngayinye ehluka phakathi kuka-99 ng kuya ku-520 ng, kuya ngohlobo lwe-blueberry. Ukubeka lokhu ngombono, i-punnet yama-blueberry enesisindo esingamagremu angama-340.

Uma udle i-punnet yonke, inani eliphelele le-pterostilbene ongayithola lingu-0.03 kuya ku-0.18 mg kuphela, futhi ngokusekelwe kumthamo osetshenziswa ezifundweni zabantu ezinomkhawulo we-100mg ngosuku, lokho kungaba inani elikhulu lama-blueberries ngosuku!

Kodwa-ke, uma ubheke ukuthola ngokwemvelo uhlobo lwamazinga e-pterostilbene anikezwa yizithako zokudla, uzodinga ngempela ukuthanda amajikijolo aluhlaza, ingasaphathwa eyokuthenga isithelo esingaka. Ngokweqiniso, lokhu akwenzeki. Imithamo yokwengeza isukela ku-50 mg iye ku-1,000 mg i-capsule ngayinye.

I-Pterostilbene itholakala kuma-alimondi, amaqabunga amagilebhisi nemivini, ama-cranberries kanye namajikijolo ahlobene ne-Vaccinium, afana nama-lingonberry, ama-bilberry, nama-huckleberries.

 

I-16. Kuyini I-Pterostilbene isuselwe kwi?

I-Pterostilbene (trans-3,5-dimethoxy-4-hydroxystilbene) iyinhlanganisela ye-stilbene enesakhiwo esifana namanye ama-stilbenes adumile njenge-resveratrol noma i-piceatannol; liqanjwe ngomthombo walo wokuqala otholakele (uhlobo lwe-pterocarpus) kodwa futhi liyingxenye yamajikijolo aluhlaza kanye nemikhiqizo yamagilebhisi. Kuyi-phytoalexin (inhlanganisela ekhiqizwa izitshalo njengesivikelo kuma-parasites nezinambuzane) efana ne-resveratrol nakuba inamandla kakhulu.

 

Imithombo ye-Pterostilbene ifaka:

I-Pterocarpus marsupium (Isihlahla sase-Indian Kino) kanye ne-pterocarpus santalinus (i-Sandalwood)
Amajikijolo aluhlaza (92-550ng/g isisindo esomile)
Amagilebhisi (Vitis vinifera) amaqabunga namajikijolo
I-Anogeissus acuminata
Uhlobo lweDracaena
I-Rheum rhapoticum (impande)
Amantongomane (Arachis hypogaea)

 

17. I-Pterostilbene imithombo yemvelo

I-Pterostilbene itholakala kuma-alimondi, amajikijolo ahlukahlukene e-Vaccinium (kufaka phakathi amajikijolo aluhlaza), amaqabunga amagilebhisi nemivini, kanye ne-Pterocarpus marsupium heartwood.

 

18. Ingabe i-Pterostilbene iyi-phytoestrogen

Umndeni wama-stilbenes we-phytoestrogens uhlanganisa i-reseveratrol ne-pterostilbene evame ukutholakala ewayinini elibomvu namakinati.

 

19. Ingabe amafutha e-Pterostilbene ayancibilika 

Yebo, lona omunye womehluko phakathi kwe-Pterostilbene ne-Resveratrol futhi.Ngaphandle kwamaqembu e-methoxy i-Resveratrol ayifani ne-lipophilic (encibilika ngamafutha) njenge-pterostilbene, ngakho-ke ukuthatha kwayo amaselula kuncane kakhulu kune-pterostilbene - i-pterostilbene ingathathwa nge-lipid bible yeseli. -ungqimba kalula.

 

20. Ingabe amanzi e-Pterostilbene ayancibilika?

I-Pterostilbene cishe ayincibiliki (emanzini) kanye nenhlanganisela ene-asidi ebuthaka kakhulu (ngokusekelwe ku-pKa yayo). I-Pterostilbene ingatholakala ewayinini elivamile lamagilebhisi nelamagilebhisi, okwenza i-pterostilbene ibe yi-biomarker engaba khona ukuze kusetshenziswe le mikhiqizo yokudla.

 

21. Ingabe i-Pterostilbene iyayenyusa i-LDL? 

Yebo, i-Pterostilbene inyusa i-LDL lapho isetshenziswa ku-monotherapy. I-Pterostilbene yehlisa umfutho wegazi kubantu abadala ngemithamo engama-250 mg/ngosuku. Kubukeka sengathi kukhona amandla okunciphisa isisindo kumaqenjana athile ane-pterostilbene.

 

22. Ingabe I-Pterostilbene umfutho wegazi ophansi?

Uhlobo lwe-pterostilbene, inhlanganisela etholakala ngokwemvelo kumajikijolo aluhlaza, yehlisa umfutho wegazi kubantu abadala, ngokuya ngemiphumela yocwaningo lomtholampilo olwethulwa ngoSepthemba 20 ku-American Heart Association's 2012 Scientific Sessions on High Blood Pressure Research e-Washington, DC.

Ucwaningo olulawulwa ngokungahleliwe, olungaboni kabili, olulawulwa yi-placebo lwenziwa abacwaningi be-University of Mississippi School of Pharmacy kanye neSikole Sezokwelapha ukuze banqume ukuthi i-pterostilbene (tero-STILL-bean), iyathuthukisa impilo yenhliziyo nemithambo yegazi.

Abaphenyi bahlole isithako ezigulini ezingama-80 ezine-cholesterol ephezulu (ingqikithi ye-cholesterol engama-200 noma ngaphezulu kanye/noma i-LDL ye-cholesterol eyi-100 noma ngaphezulu). Kabili ngosuku amaviki ayisithupha kuya kwayisishiyagalombili, ababambiqhaza bathola imithamo ephezulu (125 mg) ye-pterostilbene, imithamo ephansi (50 mg) ye-pterostilbene, i-pterostilbene (50 mg) ene-extract yamagilebhisi (100 mg), noma i-placebo, kusho uDaniel M. Riche, umphenyi oyinhloko walolu cwaningo. Abaphenyi bahlole umfutho wegazi weziguli, isisindo somzimba kanye nama-lipids egazi ekuqaleni nasekupheleni kokubamba kwabo iqhaza ocwaningweni.

"Sithole umfutho wegazi we-systolic nowe-diastolic wehlile ezigulini ezithole umthamo omkhulu we-pterostilbene nokunciphisa umfutho wegazi we-systolic ezigulini ezithole umthamo ophansi we-pterostilbene nge-extract yamagilebhisi," kusho u-Riche, uprofesa osizayo we-pharmacy practice kanye nemithi UM Medical Center eJackson.

Ababambiqhaza eqenjini le-pterostilbene ephezulu (i-250 mg ngosuku) bathole ukuncipha okuphawulekayo komfutho wegazi uma kuqhathaniswa ne-placebo: i-7.8 mmHg ku-systolic BP (p ngaphansi kuka-0.01) no-7.3 mmHg ku-diastolic BP (p ngaphansi kwe-0.001).

 

23. Ingabe i-Pterostilbene iyingozi

I-Pterostilbene ithathwa njengephephile futhi ayinayo imiphumela emibi ebalulekile efika kumthamo wama-250 mg ngosuku. Abanye abantu kungenzeka baye banyusa i-cholesterol ye-LDL lapho bethatha i-pterostilbene; ukukhishwa kwembewu yamagilebhisi kuyawuchitha lo mphumela futhi kungase kubhanqwe kahle nesithasiselo se-pterostilbene.

Okwamanje azikho izifundo ngokuphepha kwe-pterostilbene ezinganeni noma kwabesifazane abakhulelwe noma abancelisa ibele. Ngenxa yokuthi le nhlanganisela ivame ukutholakala ekudleni futhi ibhekwa njengenempilo, imithamo emincane ye-pterostilbene kufanele iphephe kunoma ubani; nokho-ke, ukuqapha kuyelulekwa ngemithamo ephezulu.

Khuluma nodokotela wakho ngaphambi kokunikeza izingane i-pterostilbene noma uzithathele wena uma ukhulelwe noma uncelisa.

 

24. Ingakanani i-Pterostilbene okufanele ngiyithathe?

I-Pterostilbene ngokuvamile iphephile ukusetshenziswa kubantu ngemithamo efika ku-250 mg ngosuku. I-Pterostilbene ibekezelelwa kahle imvamisa yedosi kabili ngosuku

 

25. I-Pterostilbene ngokudla noma ngaphandle kokudla?

Ngokocwaningo okuyisiqhathaniso sokuqala esiklanywe kahle se-pterostilbene esivivinyweni somuntu esilawulwa ngokwesilinganiso somthamo. Kubonakala sengathi awukho umthelela oqondile we-pterostilbene ezilinganisweni zomsebenzi we-hepatic noma wezinso.

Mancane amathuba okuba kuhlangane i-pterostilbene ne-ADR yamathumbu (noma ngaphandle kokudla) noma ukulunywa njengoba womabili ama-ADR abikiwe enzeka ezingeni eliphansi kuphela kuqembu le-placebo kanye nethamo eliphezulu.

 

26. Ingabe kufanele uthathe i-Pterostilbene?

Uhlolo lwabantu lubonise ukuthi i-pterostilbene iphephile kufika kumthamo wama-250 mg ngosuku. Faka kule ngxube iqiniso lokuthi ivame ukutholakala ekudleni, futhi kuyacaca ukuthi i-pterostilbene ngokuvamile iphephile ukuyisebenzisa. Khumbula, nokho, ukuthi lesi sidakamizwa senyusa izinga le-cholesterol 'embi' kubasebenzisi.

 

27. Yisiphi isikhathi esingcono kakhulu sosuku sokuthatha i-Pterostilbene?

Abantu bangase babuze ” Ngingayithatha nini kangcono i-resveratrol, i-pterostilbene, i-curcumin ne-quercetin ukuze ngibe nomphumela omuhle? ”

Kungcono ukuthi idliwe ekuseni, noma kusihlwa, kodwa hhayi phakathi nosuku. Yidla ngamanzi, ngokudla okuncane (ibhulakufesi).

 

28. Yiziphi izithako eziqukethe I-Pterostilbene?

Njengoba abantu benaka kakhulu impilo, isidingo sabantu sezithasiselo sikhula usuku nosuku. Izithako ze-Pterostilbene zingenye yazo, ethandwa kakhulu ngabantu.

Isithako esiyinhloko se-Pterostilbene supplement ye-Pterostilbene powder, engasetshenziswa ukwenza izinhlobo ezahlukene, kufaka phakathi i-capsule, amaphilisi, isiphuzo ...

I-Pterostilbene njenge-molecule ye-methylated stilbene, inesakhiwo esifanayo ne-antioxidant resveratrol. I-Pterostilbene ne-resveratrol zabelana ngezinzuzo eziningi ezifanayo, okuhlanganisa ukulwa nengcindezi ye-oxidative, kodwa i-pterostilbene iboniswe inokutholakala okuphezulu kwe-bioavailability. Ngamanye amazwi, i-pterostilbene kukholakala ukuthi imuncwa futhi isetshenziswe ngumzimba kalula kakhulu kunama-phytonutrients afanayo, okuyisizathu esisodwa esenze ukuthi muva nje idonse ukunaka kwabacwaningi bezempilo.

 

29. Ingabe i-Pterostilbene ingcono kune-Resveratrol?

1). Yini i-Resveratrol

Resveratrol iyingxenye yeqembu lezinhlanganisela ezibizwa nge-polyphenols. Kucatshangwa ukuthi zenza njengama-antioxidants, avikela umzimba emonakalweni ongakubeka engcupheni enkulu yezinto ezifana nomdlavuza nesifo senhliziyo. I-Resveratrol isekela impilo yenhliziyo nemithambo yegazi, izivikelo ze-antioxidant, i-glucose metabolism, ibhalansi enempilo yokuvuvukala, nokunye. I-Pterostilbene manje isiqokwe njengefomu elinamandla kakhulu nge-bioavailability ephakeme.

 

I-Resveratrol powder (501-36-0) ulwazi oluyisisekelo

Igama I-Resveratrol powder
CAS inombolo 501-36-0
Ukuhlanzeka 98%
Igama lamakhemikhali Resveratrol
omqondofana 5 - [(1E) -2- (4-Hydroxyphenyl) ethenyl] -1,3-benzenediol; ukudluliswa kabusha kwe-Resveratrol; (E) -5- (p-Hydroxystyryl) i-resorcinol; (E) -Ukubuyekezwa kabusha; ukudlulisa-3,4 ′, 5-Trihydroxystilbene;
Formula Yamamolekhula C14H12O3
isisindo Yamamolekhula I-228.24 g / mol
I-Melting Point I-243-253 ° C
InChI Key I-LUKBXSAWLPMMSZ-OWOJBTEDSA-N
Ifomu powder emhlophe
Ukuphila okungaphelele ezifundweni, phakamisa impilo yesigamu kuze kufike emahoreni ayi-1.6
isitoreji Isimo vikela ekukhanyeni, 2-8 ° C
Isicelo Indawo encane yewayini, ehambisana nokwehliswa kwe-serum lipid kanye nokuvinjwa kokuhlanganiswa kweplatelet. I-Resveratrol iyi-inhibitor ethile ye-COX-1, futhi futhi ivimbela umsebenzi we-hydroperoxidase we-COX-1. Kuboniswe ukuvimbela imicimbi ehlotshaniswa nokuqalwa kwe-tumor, ukukhuthaza kanye nokuqhubeka.
Isithombe sephakheji
I-COA,HPLC Iyatholakala

 

2). I-Pterostilbene vs Resveratrol

-Ukuqhathaniswa kwe-Bioavailability kanye Nezinzuzo Zezempilo

Cishe eminyakeni engamashumi amabili edlule, kwatholakala ukuthi i-resveratrol yanciphisa inqubo yokuguga kwamaselula kumvubelo. Ngo-2003, uProfesa we-Harvard Medical School uDavid Sinclair, PhD, wathola ukuthi i-resveratrol yenza isakhi sofuzo sokuphila isikhathi eside esibizwa ngokuthi i-SIRT1 kanye nesigaba esiwumphumela samaprotheni e-sirtuin.

Khona-ke, indlela efanayo yacwaningwa futhi yatholakala iyiqiniso kumagundane. Uphenyo lwe-resveratrol lube seluphendukela emiphumeleni yalo empilweni yomuntu. I-Resveratrol itholakale isekela impilo yenhliziyo, izivikelo ze-antioxidant, i-glucose metabolism, ibhalansi enempilo yokuvuvukala, nokuningi. Njengoba kwabikwa imiphumela yalezi zifundo, abantu baba nesithakazelo esikhulu ekuphuzeni iwayini elibomvu eline-resveratrol kanye nokuthatha izithako ze-resveratrol.

Kodwa-ke, ezinye zezithiyo ezinkulu zokuvuna izinzuzo ze-resveratrol kubantu zibonakala ziwukutholakala kwayo okulinganiselwe kwe-bioavailability kanye nokuqedwa ngokushesha emzimbeni. Kodwa lezo zithiyo zinganqotshwa inhlanganisela esanda kuqashelwa.

Cishe eminyakeni eyi-10 ngemva kokutholakala kokuthi i-resveratrol yenza isakhi sofuzo sokuphila isikhathi eside, abacwaningi baqala ukuba nesithakazelo kumzala wabo wamangqamuzana, i-pterostilbene. Yize ikhona ekugxilweni okuphezulu kuma-blueberries kunasewayinini elibomvu, i-pterostilbene icishe ifane ngesakhiwo samakhemikhali ne-resveratrol.

Ucwaningo lokuqala lokuphepha komuntu lwe-pterostilbene lwashicilelwa ngo-2013, futhi uphenyo luye lwaqina kusukela lapho. I-Pterostilbene manje isibalwa njengohlobo olunamandla kakhulu lwe-resveratrol. Kuthiwa inikezela ngazo zonke izinzuzo ezaziwayo ngaphambili ze-resveratrol kodwa nge-bioavailability ephakeme. Ingabe lezi zimangalo ziyiqiniso? Qhubeka ufunde ukuze uthole ukuqhathanisa okuningiliziwe kwalezi zinhlanganisela ezimbili zomzala.

 

-Umehluko Wesakhiwo 

I-Resveratrol ne-pterostilbene yizinhlanganisela zezitshalo ezivele ngokwemvelo. I-Resveratrol igxile ezikhumbani zamagilebhisi nasewayinini elibomvu, kodwa futhi iye yahlukaniswa nezimpande ze-knotweed yaseJapane. I-Pterostilbene igxile kakhulu kuma-blueberries, kodwa futhi itholakale ngamanani amancane kumakinati, amagilebhisi kanye nokhokho.

I-Resveratrol ne-pterostilbene ziwela ekilasini lezinhlanganisela ezibizwa ngama-stilbenes. Lezi zinhlanganisela ze-phenolic zihlanganisa izindandatho ezimbili ezinephunga elimnandi ezinamaqembu e-hydroxyl (-OH). I-Resveratrol ne-pterostilbene zifana kakhulu ngesakhiwo, kodwa ngomzuzu owodwa-kodwa obalulekile-umehluko. I-Resveratrol inamaqembu amathathu e-hydroxyl, kanti i-pterostilbene inelilodwa kuphela. Amanye amaqembu amabili e-hydroxyl athathelwa indawo amaqembu e-methoxy (O-CH3) ku-pterostilbene.

Umehluko enanini lamaqembu e-hydroxyl ubalulekile ngoba unomthelela ekutheni i-compound igaywa ngokushesha futhi ikhishwe kanjani emzimbeni. Amaqembu amathathu e-hydroxyl ku-resveratrol asheshisa ukususwa kwe-molecule, okwenza kube inselele ukufinyelela nokugcina amazinga ancomekayo e-resveratrol egazini.

Ngeqembu elilodwa kuphela le-hydroxyl nge-molecule ngayinye, i-pterostilbene iyakwazi ukuqhubeka nokujikeleza isikhathi eside. Umehluko omncane wesakhiwo nawo wenza i-pterostilbene ibe ne-lipophilic. I-Pterostilbene ingadlula kalula kulwelwesi lwamaseli—iyenze itholakale kakhudlwana ukusekela izindlela zamaselula.

Kokubili i-resveratrol ne-pterostilbene ngokwemvelo zenzeka ngezindlela ezimbili: i-cis ne-trans. Amafomu e-trans azinzile futhi maningi ngokwendalo. Ucwaningo luphakamisa ukuthi kukho kokubili i-resveratrol ne-pterostilbene, amafomu e-trans angaphezulu kwamafomu e-cis ngokomsebenzi webhayoloji.

 

-Bioavailability kanye Half-life 

Izindaba ezinhle mayelana ne-resveratrol ne-pterostilbene ukuthi zombili zimunca kalula ngemva kokuzithatha ngomlomo, futhi ziyakwazi nokuwela umgoqo wobuchopho begazi. Izindaba ezimbi ukuthi zigaywa ngokushesha. Isikhathi sabo sokujikeleza siyadlula.

Izinga lokumuncwa kwe-resveratrol ephuma kulume lwamathumbu licishe libe ngamaphesenti angama-75, kodwa i-metabolism yayo esheshayo esibindini iphumela ekutholakaleni kwe-oral bioavailability cishe ngamaphesenti angu-1 kuphela. Lokhu kungenxa yokuthi isibindi sikhiqiza ama-resveratrol conjugates—ikakhulukazi ama-glucuronides nama-sulfate. Ocwaningweni lwe-bioavailability yabantu, amavolontiya anempilo ayi-15 lilinye lathatha i-capsule engu-500 mg ye-trans-resveratrol. Amasampula egazi athathwe ngemva kokudoswa abonise ukuthi i-resveratrol yamahhala imelela kuphela amaphesenti angu-0.28 engqikithi ye-resveratrol ejikelezayo, kanti okunye kuhlanganisa ama-conjugated glucuronides noma ama-sulfate.

Ucwaningo luphinde lwabonisa ukuthi i-resveratrol yayihlala isikhathi esifushane- ukugxila kwayo kwanda cishe ihora elilodwa ngemuva kokuyithatha. Lowo mphumela wawufana nocwaningo lwangaphambili, olwathola ukuthi isigamu sempilo ye-trans-resveratrol kwakuyihora elilodwa kuya kwamathathu kulandela umthamo owodwa.

Uma i-compound ine-bioavailability ephansi kangaka kanye nengxenye yempilo emfushane kangaka, kunzima ukugcina ukugxila ekujikelezeni kwegazi. Ucwaningo olulodwa lwathola ukuthi ngisho nalapho abantu bethatha i-150 mg ye-trans-resveratrol izikhathi eziyisithupha ngosuku, basenokugxila okuphansi kwe-plasma.

Esinye seziqhathaniso ezivame ukucashunwa ze-resveratrol ne-pterostilbene ukuthi i-oral bioavailability ye-resveratrol ingamaphesenti angu-20 kuphela, kuyilapho i-pterostilbene ifinyelela kumaphesenti angu-80. Kodwa kubalulekile ukuqaphela ukuthi la maphesenti abhekisela enanini elihlanganisiwe le-resveratrol kanye ne-resveratrol sulfate, ne-pterostilbene kanye ne-pterostilbene sulfate. Kubaluleke nakakhulu ukuqaphela ukuthi la maphesenti avela ocwaningweni olwenziwa ngamagundane kunabantu.

Okunye ukuqhathanisa okuvame ukucashunwa ukuthi uhhafu wempilo ye-pterostilbene yinde ngokuphindwe kasikhombisa kune-resveratrol. Lesi sibalo sivela ezifundweni ezimbili: Enye ibike ukuthi i-resveratrol ibe nengxenye yempilo yemizuzu eyi-14, kanti enye ibike ukuthi i-pterostilbene ibe nengxenye yempilo yemizuzu eyi-105. Futhi, lezi kwakuyizifundo zangaphambi komtholampilo ezingaqhutshwanga kubantu kodwa konogwaja, amagundane, namagundane.

Kusele imibuzo eminingi engaphenduleki. Asazi ukuthi ingabe ama-metabolite ahlanganisiwe e-resveratrol ne-pterostilbene anomsebenzi webhayoloji ezingeni lethishu (kunobunye ubufakazi bomsebenzi, nakuba bungaphansi kwe-resveratrol yamahhala). Futhi, akwaziwa ukuthi idatha ye-bioavailability ku-pterostilbene evela ezifundweni zezilwane ingahunyushwa yini kubantu.

Abacwaningi abaningi nodokotela bathatha idatha elinganiselwe esinayo kuze kube manje mayelana ne-bioavailability ye-pterostilbene nokusebenza nayo. Ngokusekelwe ezifundweni ezishiwo ngenhla, i-pterostilbene izuze idumela lokuba yindlela enamandla kakhulu netholakala nge-bioavailable ye-resveratrol.

 

-Ukuqhathaniswa Kwezinzuzo Zezempilo 

I-Resveratrol iye yacwaningwa kabanzi. Ucwaningo lokuhlola lubonisa ukuthi i-resveratrol ilungisa izindlela eziningi zamangqamuzana ezingeni lamaselula. Isebenzisana, isibonelo, nezindlela zamaselula ezihlobene nebhalansi yokuvuvukala okunempilo, i-apoptosis, kanye ne-autophagy. Iphinde ihlanganyele nezindlela ezihambisana nokuguga nokuphila isikhathi eside, njengama-telomere kanye ne-cell senescence.

Naphezu kokutholakala kwayo okuphansi kwe-bioavailability, kunobufakazi obuningi bekhono le-resveratrol lokuthuthukisa impilo kubantu. Ukuhlolwa okungahleliwe, okulawulwayo kuye kwabonisa ukuthi ukwesekwa kwe-resveratrol kusekela ukuphathwa kwesisindo esinempilo, i-metabolism ye-blood-sugar metabolism, umsebenzi wenhliziyo, isimo sengqondo, ibhalansi enempilo yokuvuvukala kanye nokucindezeleka okwenziwe nge-oxidative. Izinzuzo zezempilo ze-Resveratrol nazo zibonisiwe kwezinye izifundo eziningi, ngisho nokuhlaziywa kwe-meta.

Uma kukhulunywa nge-pterostilbene, ubufakazi bukhulu kakhulu. Ngaphandle kocwaningo lwezokuphepha olwanyatheliswa ngo-2013, kube nezinhlolo ezimbalwa kakhulu ezenziwa kubantu. Kube nocwaningo olulodwa, olwenziwa eNyuvesi yaseMississippi kubantu abadala abangama-80, oluthole ukuthi i-pterostilbene isekela umfutho wegazi onempilo kanye ne-lipid metabolism.

Iningi locwaningo nge-pterostilbene lisesigabeni sokuhlola kanye nese-preclinical. Abacwaningi bathole ukuthi i-pterostilbene isekela izindlela eziningi zamaselula ezifana ne-resveratrol-okuhlanganisa ukusekela izivikelo ze-antioxidant kanye nezindlela zokuguqula ezihilelekile ekulinganiseni okunempilo kokuvuvukala, i-apoptosis, kanye ne-autophagy. Ochwepheshe abaningi bayavuma ukuthi izindlela zamangqamuzana e-pterostilbene kufanele zithathwe njengezilingana nalezo ze-resveratrol.

 

30. Ubani okungafanele athathe i-resveratrol

Iziguli ezinokuphazamiseka kwegazi, okungabangela ukopha, kufanele ziqashwe udokotela ngenkathi zithatha lo mkhiqizo. Abantu abahlinzwayo kufanele bayeke ukusebenzisa i-resveratrol emasontweni amabili ngaphambi kokuhlinzwa futhi bangayithathi amasonto amabili ngemva kokuhlinzwa ukuze kwehliswe ingozi yokopha.

Ungathathi izithasiselo ze-resveratrol noma amanani eqile okudla kwemvelo okuqukethe i-resveratrol ngenkathi ukhulelwe noma uncelisa. Kunokuntuleka kocwaningo kule ndawo ukuze kuqinisekiswe ukuphepha. I-Resveratrol kufanele igwenywe ezinganeni.

I-Resveratrol inomsebenzi we-estrogenic omncane futhi kuze kube yilapho kwaziwa okwengeziwe, abesifazane abanomdlavuza nezinye izimo ezizwela i-estrogen kufanele bafune iseluleko sezokwelapha ngaphambi kokuthatha i-resveratrol.

I-Resveratrol inciphisa umsebenzi wama-enzyme abandakanyeka kumetabolism yezidakamizwa kodwa ukuthi inomphumela obalulekile kubantu akuzange kufundwe.

 

31. Ingakanani i-resveratrol ephephile?

Izithako ze-Resveratrol kungenzeka ziphephile uma zithathwa ngomlomo ngemithamo efika ku-1500 mg nsuku zonke kuze kufike ezinyangeni ezi-3. Imithamo ephakeme efika ku-2000-3000 mg nsuku zonke isetshenziswe ngokuphepha izinyanga ezi-2-6. Kodwa le mithamo ephakeme kunamathuba amaningi okuthi ibangele ukucasuka kwesisu.

 

32. I-Pterostilbene ene-caffeine

I-caffeine iyi-methylxanthine etholakala kubhontshisi wekhofi, kubhontshisi kakhokho kanye nasetiyeni. Ucwaningo lubonisa ukuthi i-caffeine iyisikhuthazi sobuchopho esandisa ukuqapha, ukuphaphama, ukunaka, inkumbulo yokusebenza, nokusebenza kwemoto.

Kunomkhiqizo oyinhlanganisela enelungelo lobunikazi ebopha i-caffeine ne-pterostilbene enamandla yokulwa ne-antioxidant. Ukubophezela i-caffeine nge-pterostilbene kunciphisa kakhulu izinga lokumuncwa kwe-caffeine okwelula ingxenye yempilo yayo futhi ilethe umphumela ophelele ofinyelela ku-30% kuyilapho kunciphisa izimpawu zokuphahlazeka kwe-caffeine.

 

33. I-Pterostilbene ene-quercetin 

1) Iyini i-quercetin nezinzuzo zayo

I-Quercetin i-pigment yezitshalo (flavonoid). Itholakala ezitshalweni eziningi nasekudleni, njengewayini elibomvu, u-anyanisi, itiye eliluhlaza, ama-apula namajikijolo.

I-Quercetin ine-antioxidant ne-anti-inflammatory effects engase isize ukunciphisa ukuvuvukala, ukubulala amangqamuzana omdlavuza, ukulawula ushukela wegazi, nokusiza ekuvimbeleni isifo senhliziyo.

I-Quercetin isetshenziswa kakhulu ezimweni zenhliziyo nemithambo yegazi kanye nokuvikela umdlavuza. Ibuye isetshenziselwe isifo samathambo, izifo zesinye, nesifo sikashukela, kodwa abukho ubufakazi obuqinile besayensi obusekela iningi lalokhu kusetshenziswa. Abukho futhi ubufakazi obuhle bokusekela ukusebenzisa i-quercetin ku-COVID-19.

 

2) Pterostilbene vs Quercetin

Kukhona ikilasi elikhethekile lama-antioxidant compounds abiza ama-flavonoid noma ama-polyphenols, ngakho ukudla ukudla okucebile ngezithelo ikakhulukazi imifino kungahamba ibanga elide ekugcineni unempilo.

I-Quercetin ne-pterostilbene zingama-flavonoid amabili anjalo. Kodwa-ke, ngenxa yokuthi lawa ma-antioxidants atholakala ngamanani amancane kakhulu ekudleni okuyidlanzana kuphela futhi amandla omzimba wakho okumunca esimweni sawo semvelo ampofu noma awanele, amandla akho ezinzuzo anomkhawulo.

Ngefomula ethuthukisiwe ye-Quercetin ne-Pterostilbene, sebenzisa i-technology yobungcweti ukuze ukhuphule ukutholakala kwe-bioavailability yalezi zinhlanganisela izikhathi ezingafinyelela kwezingu-20. Ngefomula ekhethekile, ungathola:

1) Isekela ukuzivikela kwakho kwemvelo ngokumelene nezinsongo zesizini.

2) Isekela impilo yamaphaphu kanye ne-bronchial tract.

3) Isekela ukukhiqizwa kwe-mitochondria entsha ebuchosheni bakho nasemisipha.

4) Isekela impendulo enempilo, evamile yomzimba.

5) Isiza ukuvikela amaseli nezicubu emonakalweni wama-radical wamahhala.

6) Isekela impendulo evamile yokuvuvukala kakade.

I-7) Ithuthukisa ukusebenza kwengqondo kulandela ukucindezeleka okukhulu ngokomzimba.

8) Isekela ukuguga kwamaselula okunempilo.

9) Isiza ukuvikela ngokumelene ne-lipid peroxidation kumaseli akho nezicubu.

10) Isekela impilo ye-metabolic.

 

34. Pterostilbene vs berberine 

I-Berberine iyinhlanganisela ye-bioactive engakhishwa ezitshalweni eziningana ezahlukene, kuhlanganise neqembu lezihlahla ezibizwa ngokuthi i-Berberis. I-HCL iwuhlobo lwe-hydrochloride ye-Berberine, inombolo ye-CAS ngu-633-65-8.

Ngokobuchwepheshe, ingeyesigaba samakhemikhali abizwa ngama-alkaloids. Unombala ophuzi, futhi uvame ukusetshenziswa njengodayi.

I-Berberine inomlando omude wokusetshenziswa emithini yendabuko yaseShayina, lapho yayisetshenziselwa ukwelapha izifo ezihlukahlukene.

Manje, isayensi yesimanje iqinisekisile ukuthi inezinzuzo ezinhle kakhulu zezinkinga ezahlukahlukene zezempilo.

I-Pterostilbene iyinto etholakala ngamanani amancane kakhulu kuma-blueberries. Ngenani elikhulu, ingathuthukisa ukuzwela kwe-insulin (R,R,R), futhi ingathuthukisa uhlobo 2 sikashukela (R,R).

Njenge-metformin, i-pterostilbene ingaphinda yenze i-AMPK (R) isebenze. Eqinisweni, i-pterostilbene yenza i-AMPK isebenze kakade ekulevelini engu-50 micromolar, kuyilapho i-metformin izuze umphumela ngethamo eliphezulu lama-2 millimolar (R).

 

35. I-Pterostilbene ne-NMN 

1) Yini i-NMN 

I-NMN imele i-nicotinamide mononucleotide, i-molecule eyenzeka ngokwemvelo kuzo zonke izinhlobo zokuphila. Ezingeni lamangqamuzana, iyi-ribo-nucleotide, okuyiyunithi yesakhiwo eyisisekelo ye-nucleic acid RNA. Ngokwesakhiwo, i-molecule yakhiwe iqembu le-nicotinamide, i-ribose neqembu le-phosphate. I-NMN iyisandulela esiqondile se-molecule ebalulekile i-nicotinamide adenine dinucleotide (NAD+) futhi ibhekwa njengengxenye ebalulekile yokwandisa amazinga e-NAD+ kumaseli.

I-NMN powder (1094-61-7) ulwazi oluyisisekelo

Igama I-NMN powder
CAS inombolo 1094-61-7
Ukuhlanzeka 99%
Igama lamakhemikhali i-beta-Nicotinamide mononucleotide
omqondofana I-3-Carbamoyl-1- [5-O- (hydroxyphosphinato) -β-D-ribofuranosyl] pyridinium
Formula Yamamolekhula C11H15N2O8P
isisindo Yamamolekhula I-334.221 g / mol
I-Melting Point > 96 ° C
InChI Key DAYLJWODMCOQEW-TURQNECASA-N
Ifomu powder emhlophe
Ukuphila okungaphelele /
isitoreji Isimo I-Hygroscopic, -20˚C Freezer, ngaphansi kwe-Inert Atmosphere
Isicelo I-Nicotinamide mononucleotide (“NMN”, “NAMN”, ne- “β-NMN”) iyi-nucleotide etholakala ku-ribose ne-nicotinamide.
I-COA,HPLC Iyatholakala
I-NMN powder I-Pterostilbene-imikhiqizo01

 

2) I-Pterostilbene ene-NMN 

Ukuhlanganisa i-pterostilbene ne-NMN (i-nicotinamide mononucleotide) kungase kube i-duo enamandla yokunciphisa inqubo yokuguga. I-NMN iyisandulela se-NAD+, i-coenzyme ebalulekile edingwa yiwo wonke amaseli emzimbeni. Ukwehla kwamazinga e-NAD+ kuholela ekwandeni kokuqhubeka kokuguga nezifo.

Kokubili i-pterostilbene ne-NMN zingabasunguli be-sirtuin, umndeni wamaprotheni alawula impilo yamaselula kanye ne-mitochondrial futhi alawule inqubo yokuguga. Ukwenyuka komsebenzi we-sirtuin, ikakhulukazi i-SIRT1, kuxhunyaniswe nokwanda kwesikhathi sokuphila kwemvubelo nezilwane. Ngenxa yokutholakala kwayo okuphezulu kwe-bioavailability, i-pterostilbene ingaba i-activator ye-sirtuin enamandla kune-resveratrol.

Ukuhlanganisa i-pterostilbene ne-NMN kungase kukhulise ukusebenza kahle kwe-NMN ngoba izishoshovu ze-sirtuin nezithuthukisi ze-NAD+ zisebenza ndawonye. Njengoba i-pterostilbene inyusa umsebenzi we-sirtuin, ukwengeza i-NMN kuvumela i-molecule eyandulelayo ukuthi yenze umsebenzi wayo oyinhloko wokuthuthukisa amazinga e-NAD+.

Empeleni, i-NMN ne-pterostilbene zisebenza ngokubambisana ukuze kuthuthukiswe impilo ye-mitochondrial futhi yehlise ijubane inqubo yokuguga, njengoba i-NMN inyusa amazinga e-NAD+ futhi zombili izinhlanganisela zenza kusebenze ama-sirtuin.

 

36. I-Pterostilbene ne-Nicotinamide riboside

1) Yini I-Nicotinamide riboside(NR)

I-Nicotinamide riboside iyilungu lomndeni kavithamini B3, ohlanganisa ne-niacin ne-niacinamide. Itholakala izithelo, imifino, inyama, nobisi.

I-Nicotinamide riboside ishintshwa emzimbeni ibe yikhemikhali ebizwa nge-NAD+. Umzimba udinga i-NAD+ ukuze izinqubo eziningi zisebenze ngokujwayelekile. Amazinga aphansi angabangela izinkinga zempilo. Ukuthatha i-nicotinamide riboside kungasiza ukuphakamisa amazinga aphansi e-NAD+.

Abantu basebenzisa i-nicotinamide riboside ngemiphumela yokulwa nokuguga, i-cholesterol ephezulu, umfutho wegazi ophakeme, isifo se-Alzheimer, ukukhuluphala, nezinye izinjongo eziningi, kodwa abukho ubufakazi besayensi obuhle bokusekela lokhu kusetshenziswa.

Ungaphambanisi i-nicotinamide riboside ne-niacin, i-niacinamide, noma i-NADH. Zonke lezi zihlobene kodwa azifani.

 

2) Pterostilbene nge I-Nicotinamide riboside(NR)

Ezinye izithasiselo zokudla ziqukethe i-Pterostilbene ne-Nicotinamide Riboside(NR). INicotinamide riboside iyisandulela se-nicotinamide adenine dinucleotide(NAD+). Uma uthatha i-Pterostilbene nge-Nicotinamide Riboside ”NR” (Izibuyekezo), ungase ufune ukuphinde ucabangele. Uchwepheshe we-NR uDkt Charles Brenner uchaze ku-Twitter ngaphambili.

 

37. Ukuthenga kuphi I-Pterostilbene?

I-Wisepowder njengomkhiqizi oqondile, hlinzeka ngekhwalithi engcono kakhulu ye-Pterostilbene powder kusuka ku-gram-KG-Ton ukusekela isidingo samakhasimende ahlukene.