Imikhiqizo

I-Fisetin Powder (528-48-3)

I-Fisetin iyi-polyphenol ye-botanical ne-flavonoid ejwayelekile etholakala ezinhlobonhlobo zezitshalo, izithelo nemifino kubandakanya ama-strawberry, ama-apula, ama-persimmon, u-anyanisi namakhukhamba. I-Fisetin ibhekwa njengesitshalo sombala esidlulisa izithelo nemifino eminingi, njengama-strawberry, ngombala wazo nokubukeka kwawo. I-Fisetin inesakhiwo samangqamuzana esifana ncamashí nesitshalo esithandwa kakhulu i-flavonoid nesengezo sokudla i-Quercetin. Ngokungafani neQuercetin, noma kunjalo, iFisetin ingaba yi-senolytic futhi mhlawumbe enye yama-senolytics anamandla kakhulu aziwayo.

Ukwakha: Ukukhiqizwa Kweqoqwana
Iphakheji: 1KG / isikhwama, 25KG / isigubhu
I-Wisepowder inamandla okukhiqiza nokuhlinzeka ngobuningi obukhulu. Konke ukukhiqizwa ngaphansi kwesimo se-cGMP kanye nohlelo oluqinile lokulawula ikhwalithi, yonke imibhalo yokuhlola nesampula etholakalayo.

1.Iyini i-Fisetin?

2.I-Mechanism Of Action ye-Fisetin: Isebenza kanjani i-Fisetin?

3.Yikuphi ukudla okuqukethe i-Fisetin?

4.Iziphi izinzuzo ze-Fisetin?

5.Fisetin Vs Quercetin: ingabe i-fisetin iyafana ne-quercetin?

6.Fisetin Vs Resveratrol: ingabe i-fisetin ingcono kune-resveratrol?

I-7.Fisetin nokulahlekelwa isisindo

8.Ingakanani i-fisetin okufanele ngiyithathe: Umthamo we-fisetin?

9.Yini imiphumela emibi ye-fisetin?

I-10.Fisetin powder kanye ne-fisetin supplements online

 

Fisetin Chemical Base Ulwazi Ulwazi oluyisisekelo

Igama I-Fisetin Powder
CAS 528-48-3
Ukuhlanzeka 65%, 98%
Igama lamakhemikhali 2-(3,4-Dihydroxyphenyl)-3,7-dihydroxy-4H-1-benzopyran-4-one
omqondofana 2- (3,4-dihydroxyphenyl) -3,7-dihydroxychromen-4-one, 3,3 ′, 4 ′, 7-Tetrahydroxyflavone, 5-Deoxyquercetin, Natural Brown 1, CI-75620, NSC 407010, NSC 656275, I-BRN 0292829, Cotinin, 528-48-3 (anhydrous)
Formula Yamamolekhula C15H10O6
isisindo Yamamolekhula 286.24
I-Melting Point I-330 ° C (idiski)
InChI Key I-GYHFUROKCOMWNQ-UHFFFAOYSA-N
Ifomu Solid
ukubukeka Powder ophuzi
Ukuphila okungaphelele /
solubility I-Soluble ku-100 mM ku-DMSO naku-10 mM ku-ethanol
isitoreji Isimo −20 ° C isikhathi eside
Isicelo I-Fisetin iyinhlanganisela enamandla yokwenza i-sirtuin (STAC), i-antiinfigueatory kanye ne-anticancer agent
Idokhumenti yokuhlola Iyatholakala

 

I-Flavonoid polyphenols ivame ukusetshenziselwa izakhiwo zabo ze-antioxidant. Umthombo wabo oyinhloko izithelo nemifino edliwa njalo, izigidi emhlabeni wonke. Ngenxa yezinzuzo zabo zezempilo, ama-flavonoid nawo abe yizithako ezibalulekile ezithanjeni ezihlukene zokudla, ikakhulukazi i-resveratrol. Ucwaningo lwakamuva zithole i-flavonoid entsha okuyi-fisetin, okukholakala ukuthi inamandla kakhulu phakathi kwamanye ama-flavonoid asetshenziswa njengesengezo sokudla. I-Fisetin powder noma izithasiselo ze-Fisetin selokhu zanda isidingo ngenxa yezinzuzo zazo zezempilo.

 

Yini iFisetin?

I-Fisetin iyi-flavonoid polyphenol esebenza njenge-pigment ephuzi ezitshalweni. Etholwe ekuqaleni ngo-1891, i-fisetin itholakala ezithelweni eziningi nemifino efana ne-persimmon nama-strawberries. Nakuba sekunesikhathi eside ikhona, kusanda kutholwa izinzuzo ze-fisetin futhi zayenza yagqama uma iqhathaniswa nezinye izithasiselo. Ngaphezu kwalokho, kwakuyizinzuzo ezingaba khona zezokwelapha ze-fisetin powder ezakhuthaza ukucwaninga ngesihloko. Nakuba sekuhloliwe futhi izinzuzo ze-fisetic kanye nemiphumela emibi ye-fisetin iye yabonakala, kusekuningi ososayensi abangakwazanga ukukuqonda mayelana ne-flavonoid.

 

I-Mechanism Of Action ye-Fisetin: Isebenza kanjani i-Fisetin?

I-Fisetin powder isebenza ngezindlela eziningi emzimbeni womuntu. I-Fisetin isebenza ikakhulukazi emazingeni ama-antioxidants emzimbeni futhi lokhu kungenye yezinzuzo zayo ezinkulu. Ilwa nama-radicals mahhala, okungama-ion angazinzile azobamba iqhaza ekuphenduleni kwamakhemikhali ayingozi ukulimaza umzimba. Izakhiwo ze-antioxidant ze-Fisetin ziyivumela ukuthi inciphise la ma-radicals wamahhala futhi ngenxa yalokho, inciphise ingcindezi ye-oxidative umzimba ongaphansi kwayo.

Enye indlela yokusebenza ye-fisetin ukuthi ivimba indlela ye-NF-KB. Le ndlela ibalulekile ekukhiqizeni nasekukhululweni kwama-cytokines ane-pro-inflammatory futhi ekugcineni, ukuvuvukala. I-NF-KB iyindlela evimbela ukuvuvukala eyenza ukubhalwa kwezakhi zofuzo kuhlanganiswe amaprotheni avuthayo. Uma icushwe ngokwedlulele, indlela ye-NF-KB idlala indima ebalulekile ekuthuthukisweni komdlavuza, ukungezwani komzimba nezinto ezithile, kanye nezifo ezizimele. I-Fisetin powder ivimba le ndlela, ngakho-ke, isebenza njengesengezo sokulwa nokuvuvukala.

I-Fisetin powder iphinde ivimbele isenzo sendlela ye-mTOR. Le ndlela, efana nendlela ye-NF-KB, ibandakanyeka ekuthuthukiseni umdlavuza, isifo sikashukela, ukukhuluphala, kanye nezifo ze-neurodegenerative. Umzila we-mTOR ubangela amaseli ukuba athuke njengoba ezabalaza ukuhlangabezana nezidingo zamandla zendlela, okuholela ekuthwaleni umsebenzi omningi kumaseli. Lokhu kusho ukuthi amaseli asebenza ngokweqile futhi akhiqiza udoti we-metabolic kodwa asikho isikhathi esanele sokukhuculula udoti okuholela ekuqongeleleni kukadoti. Lokhu kungaba yingozi empilweni yeselula futhi ukuvinjelwa kwale ndlela nge-fisetin supplement yindlela i-fisetin esiza ngayo ukuphatha ukukhuluphala, isifo sikashukela, nomdlavuza.

Ngaphandle kwalezi zindlela ezinkulu zesenzo, i-fisetin iyakwazi futhi ukuvimbela umsebenzi wama-enzyme ehlisa i-lipid, i-lipoxygenase. Iphinde ivimbele i-matrix metalloproteinase noma umndeni we-MMP wama-enzyme. Lawa ma-enzyme abalulekile ukuze amangqamuzana anomdlavuza akwazi ukuhlasela ezinye izicubu, noma kunjalo, ngokusetshenziswa kwe-fisetin powder, lokho akwenzeki.

 

Yikuphi ukudla okuqukethe i-Fisetin?

I-Fisetin iyi-flavone esekwe esitshalweni ekhishwa ngokuyinhloko kuma-apula nama-strawberries. Kuyi-pigment yombala ophuzi kanye ne-ocher ezitshalweni, okusho ukuthi izithelo nemifino eminingi yalowo mbala inothe nge-fisetin. I-Fisetin, ezitshalweni, ikhiqizwa ku-amino acid phenylalanine, futhi ukunqwabelana kwale flavone ezitshalweni kuncike kakhulu endaweni yesitshalo. Uma isitshalo sivezwa amaza amafushane emisebe ye-UV, khona-ke kukhona ukwanda kokukhiqizwa kwe-fisetin. I-Fisetin powder yenziwa ngokuhlukaniswa kwe-fisetin emithonjeni yezitshalo elandelayo.

 

Imithombo yezitshalo Inani le-Fisetin

(μg /g)

I-Toxicodendron vernicifluum 15000
ijikijolo 160
Apple 26
I-Persimmon 10.6
U-anyanini 4.8
Izimpande zeLotus 5.8
Amagilebhisi 3.9
I-Kiwifruit 2.0
ipentshisi 0.6
Ikhukhamba 0.1
Utamatisi 0.1

 

Yiziphi izinzuzo ze-Fisetin?

Izinzuzo ze-Fisetin zimbalwa, futhi zonke zibonwe kumamodeli ezilwane. Alukho ucwaningo olukwazile ukunquma ngokuphelele lezi zinzuzo kubantu njengoba izifundo eziningi zisasesigabeni somtholampilo. Izinzuzo ezihlukene ze-fisetin zifaka:

 

Ukulwa nokuguga

Ukuguga komzimba kubonakala ngokwanda kwamangqamuzana amhlophe, angasakwazi ukuhlukana. Lawa maseli akhipha izimpawu zokuvuvukala, okuholela ezinkingeni zokuguga ezivame ukubonakala. Iziyaluyalu eziningi ezihlobene nobudala zibangelwa ukuvuvukala okunyanyekayo emzimbeni okugqugquzelwa amaseli e-sescent. Ukusetshenziswa kwe-Fisetin powder kuhloswe kulawa maseli futhi awasuse emzimbeni, ngakho-ke, ukunciphisa ukuvuvukala nokunciphisa inqubo yokuguga.

 

Ukuphathwa kwesifo sikashukela

Kumamodeli ezilwane, isithasiselo se-fisetin siboniswe ukunciphisa amazinga kashukela egazini kakhulu. Lo mphumela we-fisetin uvela emandleni e-flavonoid okwandisa amazinga e-insulin, andise ukwakheka kwe-glycogen, nokunciphisa amandla esibindi okuqalisa i-gluconeogenesis. Ngokuyisisekelo, i-fisetin isebenza kuzo zonke izindlela emzimbeni eziholela ekukhiqizweni kweglucose futhi imise leyo ngenkathi ivula izindlela ezigcina noma zisebenzisa i-glucose egazini.

 

I-anti-Cancer

Imiphumela yokulwa nomdlavuza ye-fisetin powder iyahluka ngokusekelwe ohlotsheni lomdlavuza. Ocwaningweni olwenziwa ngomdlavuza wendlala yesinye, i-fisetin ikwazile ukwehlisa ukukhula komdlavuza ngokuvimba ama-testosterone nama-DHT receptors, abalulekile ekukhuleni komdlavuza wendlala yesinye. Kolunye ucwaningo lapho umdlavuza ocwaningwayo kwakuwumdlavuza wamaphaphu, i-fisetin supplements ikwazile ukukhulisa ama-antioxidants egazini eyancipha ukusetshenziswa kukagwayi. I-Fisetin iphinde yakwazi ukwehlisa ukukhula komdlavuza wamaphaphu ngamaphesenti angama-67 iyodwa, namaphesenti angama-92 lapho ihlanganiswa nesidakamizwa se-chemotherapy. Uma isetshenziselwa umdlavuza wekoloni, i-fisetin inciphise kakhulu ukuvuvukala okuhlobene nomdlavuza wekoloni. Ucwaningo, nokho, aluzange lukhulume noma yimuphi umphumela we-fisetin ekukhuleni komdlavuza.

 

I-Neuroprotective

Lapho amagundane amadala anokuncipha kwengqondo okuhlobene neminyaka enikezwa i-fisetin supplement, kwaba nokuthuthuka okuphawulekayo kumakhono abo okuqonda kanye nenkumbulo. Kolunye ucwaningo, amamodeli ezilwane achayeka entweni eyi-neurotoxic futhi anikezwa isithasiselo se-fisetin. Izifundo zokuhlolwa zitholwe zingalahlekelwanga yinkumbulo ngenxa yesengezo. Kodwa-ke, akwaziwa ukuthi i-fisetin ingakwazi yini ukweqa umgoqo wegazi nobuchopho bomuntu ngokusebenza kahle okufana nokuvinjelwa kobuchopho begazi lamagundane.

I-Fisetin iphinde ibe yi-neuroprotective ngomqondo wokuthi ivimbela ukuthuthukiswa kwezinkinga ze-neurodegenerative ezifana ne-Alzheimer's ngokunciphisa ukunqwabelana kwamaprotheni ayingozi ebuchosheni. Ngokufanayo, amagundane ane-ALS abonise ukuthuthukiswa kwebhalansi yawo kanye nokusebenzisana kwemisipha ngemva kokunikezwa i-fisetin powder. Baphinde baphila isikhathi eside kunalokho obekulindelekile.

 

I-Cardioprotective

Abacwaningi bafunde umphumela we-fisetin powder emazingeni e-cholesterol amagundane adla ukudla okunamafutha amaningi. Isamba se-cholesterol ne-LDL kwatholakala ukuthi ehle kakhulu kuyilapho amazinga e-HDL acishe aphindeka kabili. Indlela ecatshangelwayo lapho i-fisetin ikhipha ngayo i-cholesterol emzimbeni kukholakala ukuthi ikhuphula ukukhululwa kwayo ibe yinyongo. I-cholesterol encishisiwe, iyonke, inomphumela we-cardioprotective.

Zonke lezi zinzuzo ze-fisetin zikhomba ekulweni nokuguga kanye nempilo ende okufanele yanele ukugqugquzela izifundo zomtholampilo ezengeziwe ukuze ikhemikhali igunyaze ukusetshenziswa komuthi.

 

I-Fisetin Vs Quercetin: ingabe i-fisetin iyafana ne-quercetin?

I-Quercetin ne-Fisetin womabili ama-flavonoid ezitshalo noma ama-pigment aziwa kakhulu ngezakhiwo zawo zokulwa nokuvuvukala kanye ne-anti-oxidant. Zombili futhi zinezakhiwo ezibalulekile zokulwa nokuguga, ezizenza ngokususa amaseli abomvu emzimbeni. I-Fisetin powder, noma kunjalo, iboniswe ukususa amangqamuzana ngokukhula okusebenzayo kanye namandla kune-quercetin.

 

I-Fisetin Vs Resveratrol: ingabe i-fisetin ingcono kune-resveratrol?

I-Resveratrol iyi-polyphenol futhi edume kakhulu ngezindawo zayo zokulwa ne-oxidant. Ukuthatha i-quercetin ne-resveratrol kubangela umphumela we-synergistic emzimbeni, nakuba i-quercetin inamandla kakhulu ekulamuleni ukuvuvukala nokulawula ukumelana ne-insulin. Njengoba i-Fisetin ingcono ekwenzeni le misebenzi kune-quercetin, kungaphethwa ngokuthi i-fisetin supplement ingcono kune-quercetin. izengezo ze-resveratrol.

 

I-Fisetin nokunciphisa umzimba

Abacwaningi bafunde umphumela we-fisetin powder ekuqoqweni kwamafutha emzimbeni futhi kwatholakala ukuthi ivimbela izindlela ezithile zokunciphisa ukukhuluphala okuhlobene nokudla. Iqondise indlela yokusayina ye-mTORC1. Le ndlela ibalulekile ekukhuleni kwamaseli kanye nokuhlanganiswa kwe-lipid, ngakho-ke, ikhuthaza ukunqwabelana kwamafutha emzimbeni.

 

Ingakanani i-fisetin okufanele ngiyithathe: Umthamo we-fisetin?

Umthamo we-Fisetin uhluka phakathi kwe-2 mg kuya ku-5 mg, ngekhilogremu ngayinye yesisindo, noma kunjalo, lesi akusona isiqondiso esinconywayo somthamo. Asikho isincomo esiqondile somthamo wokusetshenziswa kwe-fisetin, futhi ukukhuluma nochwepheshe bezokwelapha kungasiza ekunqumeni ububanzi bemithamo ye-fisetin, eqondene nezimo zomuntu siqu. Kwesinye sezifundo eziqhutshwa ngenhloso yokuhlola umphumela we-fisetin powder ekuvuvukeni okubangelwa umdlavuza wekoloni, i-100 mg ngosuku yayidingeka ukuze ibone ukunciphisa okukhulu kokuvuvukala.

 

Iyini imiphumela emibi ye-fisetin?

I-Fisetin isanda kuba yisihloko sezifundo eziningi nezingcezu ezahlukene zocwaningo. Le ntshisekelo yakamuva ku-flavonoid isho ukuthi ucwaningo oluningi olwenziwe bekulimodeli yezilwane noma endaweni yelebhu. Azikho izifundo eziningi zabantu ezenziwe ukuze kutholwe ngokuphelele imiphumela emibi engaba khona kanye nobuthi besengezo. Amamodeli ezilwane ekuchayekeni imithamo ephezulu ye-fisetin supplement awazange abonise imiphumela emibi, ekhomba ekuphepheni kwesengezo.

Kodwa-ke, kubalulekile ukukhumbula ukuthi ukuntuleka kwemiphumela emibi kumamodeli ezilwane akusho ukuthi ingozi yemiphumela emibi kubantu ayikho. Ukuze kufinyelelwe kuleso siphetho, izifundo zomtholampilo ezengeziwe zidinga ukwenziwa. Ocwaningweni olulodwa olwenziwa ezigulini ezinomdlavuza ukuze kuhlolwe ukusebenza kahle kwe-fisetin powder ekulawuleni izimpawu zomdlavuza, kokubili amaqembu e-placebo kanye namaqembu okulawula abike ukungakhululeki kwesisu. Njengoba umphumela ohlangothini wawukhona kuwo womabili amaqembu, futhi amaqembu womabili athola i-chemotherapy ngesikhathi esifanayo, kunzima ukuphetha ngokuthi ukusetshenziswa kwe-fisetin powder kungabangela ukungakhululeki kwesisu.

I-Fisetin powder ingase ingabi nemiphumela emibi ebikiwe kodwa isebenzisana nezidakamizwa ezithile, okuholela ekuguqulweni kwe-metabolism yalezo zidakamizwa. I-Fisetin yatholakala yehlisa izinga likashukela egazini kumamodeli ezilwane, okuyinzuzo impela ngokwayo. Kodwa uma kuthathwa ngokuhambisana nemithi elwa nesifo sikashukela, umphumela wokunciphisa i-glucose kokubili, isithasiselo kanye nomuthi kungase kube ihaba. Lokhu kungase kubangele izinkinga zempilo ezimbalwa.

I-Fisetin powder igaywa yisibindi, ngendlela efanayo, ukuthi izidakamizwa zegazi zenziwe nge-metabolized. Ngenxa yalokhu, kucatshangelwa ukuthi laba ababili bazosebenzisana nomunye nomunye futhi i-Fisetin powder izokwandisa imiphumela ye-blood-thinning agents.

 

I-Fisetin powder kanye ne-fisetin supplements online

I-Fisetin powder ingathengwa ku-inthanethi kubakhiqizi abahlukene be-fisetin powder, ngamanani asekelwe esidingweni esithile. Ukuthenga amanani enqwaba ye-fisetin kungasiza namanani entengo. Intengo ye-Fisetin ayikona lokho ngaphandle kwebanga, futhi ikububanzi obufanayo nezinye izithasiselo ze-flavonoid.

Uma ufuna ukuthenga isithasiselo se-fisetin, kubalulekile ukubheka kahle abakhiqizi be-fisetin powder kanye nenqubo yabo yokukhiqiza. Lokhu okokuqinisekisa ukuthi imihlahlandlela efanele yokuphepha kanye nezinqubo zokukhiqiza ziyalandelwa ngesikhathi sokukhiqizwa kwesithasiselo se-fisetin. Kubalulekile ukuthenga i-fisetin powder emsulwa njengoba yenza isithasiselo esihle kakhulu se-fisetin. Uma umphakeli engazilandeli izimiso zokuphepha ekukhishweni nasekuhlanganiseni i-fisetin, umkhiqizo wokugcina ungangcoliswa noma ungcoliswe izithako eziyingozi empilweni yomuntu noma ezingenamthelela empilweni yomuntu, noma ngabe yikuphi. Noma iyiphi indlela, izinzuzo ze-fisetin bezingeke zibe khona naphezu kokuthatha isengezo isikhathi eside.

Kubalulekile ngaso sonke isikhathi ukubheka izithako ze-fisetin powder ezithengwayo kanye nesilinganiso sokuhlushwa salezi zithako ukuqinisekisa ukuthi i-fisetin powder ehlanzekile iyathengwa. Uma lo mehluko ungenziwanga, khona-ke kukhona amathuba amakhulu okwanda kwemiphumela emibi ye-fisetin kanye/noma izinzuzo ezincishisiwe ze-fisetin, sezizonke.

 

Okubhekwayo

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527824/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261287/

https://pubmed.ncbi.nlm.nih.gov/29275961/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780350/

https://link.springer.com/article/10.1007/s10792-014-0029-3

https://pubmed.ncbi.nlm.nih.gov/29541713/

https://pubmed.ncbi.nlm.nih.gov/18922931/

https://pubmed.ncbi.nlm.nih.gov/17050681/

https://pubmed.ncbi.nlm.nih.gov/29559385/