Konke okudingeka Ukwazi NgeNicotinamide Riboside Chloride

Izigidi zabantu laphaya zisebenzisa imali eningi kwimikhiqizo yokulwa nokuguga efana I-Nicotinamide Riboside chloride. Noma ukuguga kuyinqubo yemvelo, abantu abafuni ukubukeka bebadala. Izindaba ezimnandi ukuthi, kunemikhiqizo eminingana ngaphandle lapho engasiza ngalokhu futhi iNicotinamide Riboside Chloride ungomunye wayo. Kulesi sikhathi, sizobe sigxile kumkhiqizo.

Sizokunikeza imininingwane ngayo, ukuthi isebenza kanjani, izinzuzo zayo, ukuthi ungayithenga kuphi, nezeluleko ezingeziwe zokukusiza wenze kangcono kakhulu kulo.

Yini iNicotinamide Riboside Chloride?

Ngakho-ke, ake siqale ngombuzo oyisisekelo kunazo zonke. Khohlwa ngegama elikhulu nelinkimbinkimbi. I-Nicotinamide Riboside Chloride CAS 23111-00-4 empeleni iyindlela ehlukile ye-Vitamin B3, evame ukubizwa nge- niacin. INicotinamide Riboside Chloride nayo ingabizwa nge-niagen noma ifinyezwe njenge-NR. Uma usungenile emzimbeni, uzoguqulwa uguqulwe I-Nicotinamide adenine dinucleotide noma i-NAD +. I-NAD + ingenye yama-enzyme abaluleke kakhulu kumzimba womuntu.

Inesibopho sokuphoqelela inani lezinqubo ezibalulekile zemvelo kufaka phakathi ukuguqulwa kokudla kube amandla nokuqinisa amasistimu okuvikela atholakala esitokisini ngasinye. I-enzyme nayo ingahle ibaluleke kakhulu ekulungiseni iDNA eyonakele futhi ingaba nomphumela omuhle owengeziwe ekuthuthukiseni ukuguga okunempilo. Umzimba ungakhiqiza i-enzyme yayo ye-NAD + kalula ngaphandle kokufaka. Ingxenye edabukisayo ukuthi, njengoba uqhubeka ukuguga, inani le-NAD + elikhiqizwa ngumzimba liyancipha.

Ngamafuphi, abantu asebekhulile bazoba namazinga aphansi alesi simiso semvelo esibalulekile uma kuqhathaniswa nabancane. Yilapho-ke ukungezelela kubaluleke kakhulu. Kusetshenziswa izithasiselo zeNicotinamide Riboside Chloride ukuthuthukisa amazinga we-NAD +, ikakhulukazi phakathi kwabantu asebekhulile, kunganikeza ngenzuzo enkulu emangalisayo.

Okokuqala, amazinga ancipha e-NAD + afaniswe nokugula okungalapheki okuhlobene nobudala kubandakanya isifo sikashukela, i-Alzheimer's, ukuhluleka kwenhliziyo, kanye nokulahlekelwa umbono. Kukhona futhi ubufakazi obukhombisa ukuthi ukukhuphuka kweNAD + kungahle kuguqule izimpawu zokuguga. Ekugcineni, ukusetshenziswa kwesithasiselo se-Nicotinamide Riboside chloride akusizi kuphela ukuthi ubukeke umncane futhi uqiniseka ngokwengeziwe. Kuyasiza futhi ukwehlisa ingozi engaba khona yezifo ezingamahlalakhona njengoba usukhula.

Ngabe isebenza kanjani iNicotinamide Riboside Chloride?

Inhloso yokuqala yeNicotinamide Riboside chloride vs niacin supplementation ukuthuthukisa amazinga e-NAD + emzimbeni. I-NR iyi-vithamini etholakala kokulandela okuncane kakhulu ekudleni kwethu okujwayelekile. Lapho into isidakiwe, izoguqulwa ngezinqubo ezijwayelekile ze-metabolic ibe yi-NAD +. Okwenza i-NR ibe yicebo elihle kubantu abafuna ukwengeza amazinga we-NAD + iqiniso lokuthi litholakala kakhulu nge-bioavava.

Njengoba sesiphawulile ngenhla, i-NR iyindlela yeVitamin B3. Kunemithombo eminingi yokudla laphaya engahambisa uVitamin B3. Kodwa-ke, izinga lapho iNicotinamide Riboside Chloride imunca emzimbeni lishesha ngokuqhathaniswa namanye amafomu weB3 ekudleni. Lokhu kwenza kube ngenye yezindlela ezinokwethenjelwa nezisebenzayo zokungezelela kwe-NAD + emzimbeni womuntu.

Inzuzo / Imiphumela yeNicotinamide Riboside Chloride

Izinzuzo zeNicotinamide Riboside Chloride zingabukwa kuphela maqondana neqhaza elidlalwe yi-NAD + emzimbeni.

Lokhu kungenxa yokuthi ukuxhaswa kwe-NR kuzonyusa amazinga e-NAD + bese kuthi le coenzyme ebalulekile izoletha okulandelayo Izinzuzo zeNicotinamide Riboside Chloride:

1. Ukuguga Okusempilweni

Ukukhiqizwa okwandayo kwe-NAD + emzimbeni kungahle kudale ukukhiqizwa kwama-enzyme athile angasiza ukukhulisa ukuguga okunempilo nokunomusa. Ezifundweni zezilwane, i-coenzyme ikwazile ukuqala ukukhiqizwa kwe-enzyme ebizwa nge- sirtuins.

ISirtuins yabonakala ithuthukisa isikhathi sokuphila nempilo ejwayelekile yezifundo zokuhlolwa kwezilwane ngesikhathi sesifundo semitholampilo. Olunye ucwaningo luphinde lukhombise ukuthi amaSirtuins angasiza ukukhulisa ukumelana kwengcindezi kubantu nokulungisa iDNA eyonakele.

2. Thuthukisa I-Cell Defense Mechanism ku-Brain

I-NAD + ingavikela futhi namaseli obuchopho ekuwohlokeni okungajwayelekile, ikakhulukazi ngokuguga. Olunye ucwaningo lukhombisa ukuthi i-NAD + ingalawula ukukhiqizwa kwamaprotheni abizwa nge-PGC-1-alpha. Iprotheni ibaluleke kakhulu ekuvikeleni amaseli ekucindezelekeni kwe-oxidative. Kungase futhi kuthuthukise futhi kulungiswe imisebenzi ye-mitochondrial kumaseli wobuchopho, okuholela empilweni engcono yokuqonda.

Kukhona futhi nezifundo eziningi zocwaningo ezixhumanisa ukucindezelwa kwama-oxidative kanye nokusebenza kwemitochondrial ezilimele kumaseli wobuchopho nokuphazamiseka kobuchopho okuhlobene nobudala njenge-Alzheimer's, Parkinson nabanye. Isenzo se-NAD + ekwehliseni lezi zinqubo singanciphisa kakhulu ubungozi I-Alzheimer's nezinye izifo zobuchopho eziwohlokayo.

Ukusebenza kwe-NAD + kulokhu empeleni kuphezulu kakhulu. Kwezinye izifundo zezilwane lapho amagundane aphethwe i-Alzheimer's neNicotinamide Riboside Chloride, amazinga e-PGC-1-alpha ebuchosheni akhuphuka phakathi kuka-50 no-70%. Ekupheleni kwezifundo, amagundane aphathwe nge-NR akhombisa ukuthuthuka okukhulu emisebenzini esekwe kwimemori.

3. I-Nicotinamide Riboside Chloride May Isiza Ngezinkinga Zenhliziyo

Ingozi yokwehluleka kwenhliziyo inyuka kakhulu ngokuguga. Ukwehluleka kwenhliziyo nakho kuyinkinga ejwayelekile empeleni yimbangela yokuqala yokufa emhlabeni jikelele. Impilo yenhliziyo iyonke incike ezicini eziningi yize kufaka phakathi ukudla okufanele nokuzivocavoca. Kepha kunezinto ezithile ezinganciphisa ubungozi. Ukukhiqizwa okwandisiwe kwe-NAD + kungenye yalezi zinto.

Ucwaningo olwenziwe ezilwaneni lwathola ukuthi ukukhiqizwa okwandayo kwe-NAD + kusize ekuguquleni emuva ushintsho olungaba yingozi emithanjeni yegazi ebangelwa ukuguga. Kwezinye izifundo ezenziwa ngabantu, amazinga aphezulu we-NAD + aholele ekwehlisweni kokuqina kwe-aorta. I-NAD + nayo yabikwa ukuthi yehlisa ingozi engaba khona yokucindezela kwegazi kwe-systolic.

Lokhu kumane kusho ukuthi kukhona amandla wangempela wokusebenzisa iNicotinamide Riboside Chloride njengesengezo esinokwenzeka ekunciphiseni ubungozi besifo senhliziyo. Kodwa-ke, kusadingeka ukuthi kube nocwaningo olwengeziwe lwabantu lokuqonda kangcono amandla.

Ngaphezu kwalezi zinzuzo, i-Nicotinamide Riboside chloride nayo ingasiza nge Ukwehla kwesisindo. Lokhu kungenxa yokuthi amazinga aphakeme we-NAD + anganyusa amanani we-metabolism emzimbeni. Amazinga aphezulu we-NAD + futhi avikela ukulimala kwe-DNA nokucindezela kwe-oxidative, izici ezimbili ezihlangene nomdlavuza. I-coenzyme nayo ingaba nemiphumela emihle ekuthuthukiseni ukuguga kwemisipha enempilo.

Ungayisebenzisa kanjani iNicotinamide Riboside Chloride

INicotinamide Riboside Chloride ithengiswa kakhulu njenge-niagen. Umkhiqizo uthengiswa emaphaketheni ku-inthanethi futhi udliwe usebenzisa umlomo.

Yize iningi lemikhiqizo ye-niagen iqukethe iNicotinamide Riboside Chloride nje, eminye ingaba nezici ezengeziwe ezibandakanya i-polyphenol noma iPterostilbene. Abakhiqizi bavame ukutusa umthamo we-Nicotinamide Riboside chloride dosage ephakathi kwama-250 mgs kanye nama-300 mgs ngosuku. Lokhu kucishe kufane namaphilisi amabili womkhiqizo usuku ngalunye.

INicotinamide Riboside Chloride vs Nicotinamide Riboside (NR)

Umehluko kuphela phakathi kwalezi zinto ezimbili ukwakheka. Kodwa-ke, banendlela ecishe ifane yokusebenza. Umsebenzi wabo bobabili beNicotinamide Riboside Chloride neNicotinamide Riboside ukuthuthukisa ukukhiqizwa kwe-NAD + emzimbeni. Lezi zindlela futhi ezingezinye zezindlela zikaVitamin B3.

INicotinamide Riboside Chloride vs Nicotinamide Mononucleotide (NMN)

Impikiswano yeNicotinamide Riboside chloride vs I-NMN akuyona into enkulu kangako. INicotinamide Mononucleotide (NMN), njengeNicotinamide Riboside Chloride, itholakala kwe-niacin. Lezi zinto ezimbili nazo ziyafana ngendlela ezisebenza ngayo. Angeniswa futhi aguqulwa abe yi-NAD + uma nje engena emzimbeni womuntu. Ngaphezu kwalokho, zombili lezi zinto zenziwe futhi ngokuhlanganiswa kusuka ekuhlanganeni kwembambo neNicotinamide.

Yini Ukudla Okuqukethe I-Nicotinamide Riboside?

Ukudla kwethu okuningi kuqukethe inani elincane kakhulu leNicotinamide Riboside. Kodwa-ke, kubantu abaningi, ukudla okujwayelekile, okunemithamo yeVitamin B3, kufanele kube nokwanele ukunikeza umthamo odingekayo weNicotinamide Riboside.

Nakhu ukudla okuningana okungasiza ngalokhu:

• Ubisi lobisi- Ubisi lwenkomo luza lulayishwe ngeNicotinamide Riboside eningi.
• Fish- Ungase futhi uthole i-NR kusuka ku-Fish. I-tuna, ama-sardine, ne-salmon konke kunamazinga amahle kakhulu weNicotinamide Riboside.
• Ubhiya- Ngokumangazayo, ubhiya lungakusiza nokuthi ungeze iNicotinamide Riboside. Lokhu kungenxa yokuthi ubhiya unemvubelo njengenye yezithako zawo eziyinhloko futhi imvubelo yaziwa ngokuthi iphezulu kakhulu ku-NR.
• Inyama yenkukhu- Ukudla inkukhu kungakhuphula namazinga e-NR emzimbeni wakho. Ukuhanjiswa kwenkukhu, okugazingiwe, okuthosiwe, noma okuyisitshulu, kuqukethe ama-milligram angafika ku-9.1 eNicotinamide Riboside.
• Imifino eluhlaza- Imifino eluhlaza nayo iyelulekwa. Zilayishwe inqwaba yamavithamini, kufaka phakathi i-B3 ebaluleke kakhulu ezobaluleka ekuhlanganisweni kwe-NAD + emzimbeni wakho.
• Imvubelo - Okokugcina, uma ungakwazi ukuthola iNicotinamide Riboside eyanele kubhiya, mhlawumbe ungafuna ukumunca imvubelo ngokuhlukile. Imvubelo iphezulu kakhulu kuNicotinamide Riboside futhi kufanele ifakwe ekudleni kwakho.

Ingabe iNicotinamide Riboside Chloride Iphephile?

I-Nicotinamide Riboside chloride bulk iyisengezo esiphephe kakhulu ukusebenzisa kodwa njenganoma yimuphi umkhiqizo, inemiphumela emibi eminingana okufanele ngabe uyayazi. Kwezinye izifundo zabantu, izifundo zokuhlola zinikezwe phakathi kwama-milligrams ayi-1000 nama-milligrams angama-2000 weNicotinamide Riboside Chloride futhi azange zifumane imiphumela elimazayo. Kuze kube manje, abakhiqizi beNicotinamide Riboside Chloride batusa phakathi kwe-200 mgs ne-300 mgs yomkhiqizo ngosuku.

Naphezu kwaleli rekhodi lokuphepha, iNicotinamide Riboside Chloride ingaba nemiphumela emibi embalwa okufanele uyikhumbule. Okokuqala, abanye abantu baye babika ukuthi bazizwa bexinekile ngemuva kokusebenzisa umkhiqizo. Kwezinye izimo, iziguli zazizizwa zikhathele futhi zinekhanda ngenxa yeNicotinamide Riboside Chloride. Akukona kujwayelekile ukuzwa nezinkinga zokugaya ukudla kubandakanya ukungakhululeki kwesisu nohudo.

Kodwa-ke, ubulukhuni beNicotinamide Riboside chloride imiphumela emibi ihluke kakhulu kumuntu nomuntu. Abanye abantu abayitholi neze le miphumela. Uma ngabe uneminye umuthi, khuluma nodokotela wakho kuqala ngaphambi kokusebenzisa iNicotinamide Riboside Chloride.

I-Nicotinamide Riboside Chloride Thenga ku-Inthanethi

Uma uzizwa sengathi iNicotinamide Riboside Chloride inganikeza izinzuzo ezinhle ngempilo yakho iyonke, lapho-ke uzokujabulela ukwazi ukuthi umkhiqizo uyatholakala ezitolo eziningi. Ungathenga futhi online noma okungaxhunyiwe ku-inthanethi. INicotinamide Riboside Chloride ithengiswa kakhulu njenge-niacin. Kufika namaphilisi.

Noma kunjalo, ungafuna ukuthatha isikhathi sakho njengoba ufuna umthengi. Noma kunabathengisi abaningi abazokunikeza umkhiqizo wekhwalithi, sisekhona isibalo esikhulu seziza ezingezona iqiniso ezifuna ukukukhwabanisa.

Nawa amanye amathiphu azokusiza uthole abathengisi boqobo:

• Bheka izibuyekezo. Kuhlale kungumbono omuhle ukwazi ukuthi abanye abathengi bathini ngomthengisi ngaphambi kokuthenga.
• Bheka amanani futhi. Noma I-Nicotinamide Riboside Chloride buy akubizi kakhulu, futhi akubizi kangako. Abathengisi abathengisa umkhiqizo ngamanani aphansi ngokungenangqondo kufanele bagwenywe.
• Kungaba futhi umqondo omuhle ukucela isincomo esiqondile. Esikhundleni sokuvele ugxume ku-inthanethi futhi uzame ukuthola izithasiselo zeNicotinamide Riboside Chloride, khuluma nothile owake wathenga le mikhiqizo ngaphambili futhi ubone ukuthi bangakuxhumanisa nomthengisi weqiniso. Odokotela nabo bangaba nemibono ethile yokuthi ungaqala kuphi futhi neminye imininingwane ngeNicotinamide Riboside chloride vs NADH.

INicotinamide Riboside Chloride iyisengezo esithandwa kakhulu ekulweni nokuguga. Kungasiza ukuguqula izimpawu zokuguga futhi kukugcine usezingeni elifanele. Isiqondisi esingenhla kufanele sikusize uthole umkhiqizo wangempela laphaya.

Isihloko ngu:

UDkt Liang

Co-founder, ubuholi benkampani obuyinhloko bokuphatha I-PhD itholwe kuFudan University ku-organic chemistry Isipiliyoni seminyaka engaphezu kwesishiyagalolunye emkhakheni we-organic synthesis wemithi yokwelapha. Isipiliyoni esicebile kumakhemikhali ahlanganisayo, chemistry yezokwelapha kanye nokwenziwa ngokwezifiso nokuphathwa kwephrojekthi

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