I-Gamma-aminobutyric acid (GABA) Powder 56-12-2

I-Gamma-aminobutyric acid (GABA) powder iyi-neurotransmitter engapheli elawula ukujabula kwe-neuronal, ithoni yemisipha, ukukhula kwamaseli we-stem, ukukhula kwengqondo kanye nemizwa. Ngesikhathi sokuthuthuka, i-GABA isebenza njenge-neurotransmitter ejabulisayo kepha ishintshela kamuva emsebenzini wokuvimbela. I-GABA ibonisa imisebenzi ye-anxiolytic, anticonvulsant, ne-amnestic, enciphisa ukuphumula nokunciphisa ukukhathazeka kuzilungiselelo zomtholampilo. Indima yayo eyinhloko ukunciphisa ukujabula kwe-neuronal kulo lonke uhlelo lwezinzwa. I-GABA ithengiswa njengesengezo sokudla.

Ukwakha: Ukukhiqizwa Kweqoqwana

Iphakheji: 1KG / isikhwama, 25KG / isigubhu

Isigaba: supplements

Incazelo

Ulwazi lwe-Gamma-aminobutyric acid (GABA) Powder Base

Igama	I-Gamma-aminobutyric acid (GABA) Powder
CAS	56-12-2
Ukuhlanzeka	98%
Igama lamakhemikhali	I-4-Aminobutyric acid
omqondofana	GABA; df468; gamma; (2D2); (3B7); Gammar; Immu-G; Reanal; DF 468; Gamarex
Formula Yamamolekhula	C4H9NO2
isisindo Yamamolekhula	103.12
I-Melting Point	Ngo-195 ° C (ngomhlaka.) (Kuvuliwe.)
InChI Key	I-BTCSSZJGUNDROE-UHFFFAOYSA-N
Ifomu	powder
ukubukeka	Okumhlophe noma okukhanyayo Okuphuzi
Ukuphila okungaphelele	/
solubility	I-H2O: 1 M ku-20 ° C, icacile, ayinambala
isitoreji Isimo	Gcina ku-RT.
Isicelo	I-neurotransmitter ebalulekile yokuvimbela.
Idokhumenti yokuhlola	Iyatholakala

I-Gamma-aminobutyric acid (GABA) Impuphu 56-12-2 Incazelo jikelele

I-Gamma-aminobutyric acid (GABA) powder yiyona neurotransmitter eyinhloko yokuvimbela ohlelweni lwezinzwa oluphakathi kwamamalia. Idlala indima ekulawuleni ukujabula kwe-neuronal kulo lonke uhlelo lwezinzwa. Kubantu, i-GABA nayo ibhekene ngqo nokulawulwa kwethoni yemisipha. Yize ngokwamakhemikhali iyi-amino acid, i-GABA powder akuvamile ukubizwa kanjalo emiphakathini yesayensi noma yezokwelapha, ngoba igama elithi "amino acid," elisetshenziswe ngaphandle kwesiqu, ngokujwayelekile libhekisa kuma-alpha amino acid, okungewona i-GABA, noma ingabe ihlanganiswe neprotheni. Ku-spastic diplegia kubantu, ukumuncwa kwe-GABA kuyaphazamiseka yimizwa elimele kusuka ku-motor motor neuron lesion yesimo, okuholela ku-hypertonia yemisipha ekhonjiswe yilezo zinzwa ezingasakwazi ukumunca i-GABA.

I-Gamma-aminobutyric acid (GABA) Impuphu 56-12-2 Umlando

Ngo-1883, i-GABA yahlanganiswa okokuqala, futhi yaziwa kuphela kuqala njengomkhiqizo wesitshalo nowamagciwane.

Ngo-1950, i-GABA yatholakala njengengxenye ebalulekile yohlelo lwezinzwa oluphakathi kwamammalia.

Ngo-1959, kwakhonjiswa ukuthi lapho kuthinteka khona ukuvimbela imicu yemisipha ye-crayfish i-GABA isebenza njengokukhuthaza imizwa yokuvimbela. Kokubili ukuvinjelwa ngokuvuselelwa kwemizwa nokufakwa kwe-GABA kuvinjelwe i-picrotoxin.

I-Gamma-aminobutyric acid (GABA) Impuphu 56-12-2 Mukuphawula Of Action

IGamma-aminobutyric acid (GABA) mhlawumbe imele isidlulisi esibaluleke kunazo zonke se-CNS yezilwane ezincelisayo (futhi bona iSahluko 15). Zombili lezi zinhlobo ze-GABAergic inhibition (pre- ne-postynaptic) zisebenzisa uhlobo olufanayo lwe-GABAA receptor subtype, olusebenza ngokulawulwa kwesiteshi se-chloride se-membrane ye-neuronal. Uhlobo lwesibili lwe-GABA receptor, i-GABAB, okuyi-G protein-coupled receptor ayithathwa njengebalulekile ekuqondeni indlela ye-hypnotics. Ukwenza kusebenze ukwamukelwa kwe-GABAA yi-agonist kukhulisa impendulo evimbelayo ye-synaptic yama-neurons aphakathi kwe-GABA ngokusebenzisa i-hyperpolarization. Ngoba ama-neurons amaningi, uma kungewona wonke, athola okokufaka kwe-GABAergic, lokhu kuholela enqubeni lapho umsebenzi we-CNS ungacindezelwa khona. Isibonelo, uma ama-interneuron we-GABAergic enziwe asebenza yi-agonist evimbela ukwakheka kwe-monoaminergic kwe-brainstem, umsebenzi we-hypnotic uzobonwa. Izakhiwo ezithile ze-neuronal ezifundeni ezahlukahlukene zobuchopho ezithintwe yi-GABAA agonist ziyaqhubeka nokuchazwa kangcono.

I-Gamma-aminobutyric acid (GABA) Impuphu 56-12-2 Isicelo

I-GABA isebenza ngokulawula umsebenzi wobuchopho nowezinzwa ngokuvimbela ama-neurons amaningi asebenza ebuchosheni. Ukweqiwa kwe-norepinephrine / adrenaline kungenza ubuchopho bethu buthole ukungezwani okukhulu, ukucindezelwa nokwesaba.

Umzimba wethu uhlakaniphile kulesi simo, futhi uzosebenzela ukunciphisa lokhu ngokudedela i-GABA, ezovimbela le adrenaline eyengeziwe. Ukungeza ukwengeza kwe-GABA kungasiza kakhulu ekusizeni umzimba kulokhu kuvinjelwa, nokunqoba ubusuku bokuphosa nokujika.

Ngaphandle kwe-GABA, amangqamuzana ezinzwa avutha kaningi futhi kaningi kakhulu, okuzoholela ekuphazamisekeni kokukhathazeka ngisho nasezimeni ezinjengokulutha, ukuphathwa yikhanda kanye nesifo sikaParkinson.

Okwakha umzimba:

Ukulala kubalulekile kubagijimi ngoba lesi yisikhathi lapho kwenzeka khona ukululama. Abakhi bomzimba bangazuza ekusetshenzisweni kwe-GABA ukubasiza baphumule ngemuva kokuzivocavoca okuqinile, futhi babasize bathuthukise ukulala kwabo njengengxenye yesitaki esengezelelayo.

I-Gamma-aminobutyric acid (GABA) Impuphu 56-12-2 Ucwaningo olwengeziwe

I-GABA njengesengezo:

Imithombo eminingi yezentengiso ithengisa ukwakheka kwe-GABA ukuze isetshenziswe njengesengezo sokudla, kwesinye isikhathi sokuphathwa kwezilimi ezimbalwa. Le mithombo ngokujwayelekile ithi isengezo sinomphumela wokuthula. Lezi zimangalo azikaqinisekiswa ngokwesayensi. Isibonelo, kunobufakazi obushoyo ukuthi imiphumela yokwehlisa ye-GABA ingabonakala ngokubonakalayo ebuchosheni bomuntu ngemuva kokuphathwa kwe-GABA njengesengezo somlomo. Kodwa-ke, kukhona nobufakazi bokuthi i-GABA ayiweli umngcele wegazi nobuchopho emazingeni abalulekile.

Kukhona ezinye izithako ezithengiswa ekhawunteni ezifana ne-phenylated GABA uqobo ngqo, noma i-Phenibut; kanye nePicamilon (yomibili imikhiqizo yaseSoviet cosmonaut) - I-Picamilon ihlanganisa i-niacin ne-phenylated GABA futhi yeqe isithiyo segazi-sobuchopho njengeprodrug eyathi kamuva yangena ku-GABA nase-niacin.

Isilinganiso:

Uma usebenzisa i-GABA solo, imithamo ingasuka ku-250mg ifike ku-750mg ngosuku. Njengengxenye yesitaki esengezelayo imithamo ejwayelekile iphansi kakhulu njengoba isebenza ngokubambisana nezinye izithako ezifana ne-melatonin.

I-Gamma-aminobutyric acid (GABA) Impuphu 56-12-2 Izikhombo

Ukuvimbela nokuthakazelisa ngenxa ye-gamma-aminobutyric acid ohlelweni oluphakathi lwezinzwa. UHayashi, Imvelo 1958, 182, 1076
Izenzo ezijabulisayo ze-GABA ngesikhathi sokuthuthuka: uhlobo lokukhuliswa (isibuyekezo) Y. UBen-Ari, Nat. UMfu Neurosci. 2002, 3, 728
Ama-GABA ne-GABA receptors ohlelweni oluphakathi lwezinzwa nezinye izitho (ukubuyekeza) M. Watanabe, K. Maemura, K. Kanbara, T. Tamayama, H. Hayasaki, Int. UMfu Cytol. 2002, 213, 1
U-Abdou AM, uHigashiguchi S, uHorie K, et al. Ukuphumula kanye nemiphumela yokuqinisa ukuvikelwa komzimba yokuphathwa kwe-gamma-aminobutyric acid (GABA) ebantwini. Ama-Biofactors. 2006; 26 (3): 201-8.

Imikhiqizo