I-Urolithin B Powder 1139-83-9

I-Urolithin B Powder 1139-83-9 Ulwazi oluyisisekelo

Igama	Urolithin B Powder
CAS	1139-83-9
Ukuhlanzeka	98%
Igama lamakhemikhali	I-3-Hydroxy-6H-dibenzo [b, d] pyran-6-eyodwa
omqondofana	AURORA 226; Urolithin B; AKOS BBS-00008028; 3-hydroxy urolithin; 3-hydroxy-6-benzo[c]chromenone;3-hydroxybenzo[c]chromen-6-one; 3-Hydroxy-benzo[c]chromen-6-one; 3-HYDROXY-6H-DIBENZO[B,D]PYRAN-6-ONE; 6H-Dibenzo(b,d)pyran-6-one, 3-hydroxy-;3-Hydroxy-6H-benzo[c]chromen-6-one AldrichCPR
Formula Yamamolekhula	C13H8O3
isisindo Yamamolekhula	I-212.2 g / mol
I-Melting Point	247 ° C
InChI Key	I-WXUQMTRHPNOXBV-UHFFFAOYSA-N
Ifomu	Solid
ukubukeka	I-powder nsundu ekhanyayo
Ukuphila okungaphelele	/
solubility	i-soluble5mg / mL, icacile (ifudumele)
isitoreji Isimo	I-2-8 ° C
Isicelo	I-Urolithin B iyi-metabolite yama-bacterial sebacterial ye-ellagitannis futhi ikhombisa ukusebenza okunamandla okulwa ne-oxidant kanye ne-pro-oxidant ngokuya ngohlelo nemibandela yokulinganisa. I-Urolithin B nayo ingabonisa umsebenzi we-estrogenic kanye / noma wokulwa ne-estrogenic.
Idokhumenti yokuhlola	Iyatholakala

 

I-Urolithin B Powder 1139-83-9 Incazelo jikelele

I-Urolithin B iyi-urolithin, uhlobo lwamakhompiyutha akhiqizwa esiswini somuntu ngemuva kokufakwa kokudla okuqukethe i-ellagitannins njengepomegranate, ama-sitrobheli, ama-raspberries abomvu, ama-walnuts noma newayini elibomvu le-oki. I-Urolithin B itholakala kumchamo ngesimo se-urolithin B glucuronide.

I-Urolithin B ingesinye se-gut microbial metabolites of ellagitannins, futhi inemiphumela yokulwa nokuvuvukala ne-antioxidant. I-Urolithin B ivimbela umsebenzi we-NF-κB ngokunciphisa i-phosphorylation kanye nokucekelwa phansi kwe-IκBcy, iphinde icindezele i-phosphorylation ye-JNK, i-ERK, ne-Akt, futhi ithuthukise i-phosphorylation ye-AMPK. I-Urolithin B futhi isilawuli samathambo emisipha. I-Urolithin B nayo ingabonisa umsebenzi we-estrogenic kanye / noma wokulwa ne-estrogenic.

 

I-Urolithin B Powder 1139-83-9 Umlando

I-Urolithin B ingasetshenziswa njengesidakamizwa se-antitumor kanye ne-anticancer. I-Urolithin B (CAS NO: 1139-83-9) iyi-urolithin, iphinde ikhiqizwe emathunjini omuntu ngemuva kokumunca ama-ellagitannins avela kupomegranate. I-Urolithin B inganciphisa ukulimala kwemisipha okwenzeka ngesikhathi sokuzivocavoca okukhulu futhi ivikele imisipha ekucindezelekeni okubangelwa ukudla okunamafutha aphezulu.

I-Urolithin B powder nayo iyi-metabolite microbial emathunjini ye-ellagitannis futhi ikhombisa ukusebenza okunamandla kokulwa ne-oxidant kanye ne-pro-oxidant kuye ngohlelo nemibandela ye-assay. I-Urolithin B ingakhombisa nomsebenzi we-estrogenic kanye / noma we-anti-estrogenic. Inemiphumela elwa nokuvuvukala kanye ne-antioxidant. I-Urolithin B iyasetshenziswa futhi ibe yisilawuli semisipha yamathambo.

Futhi i-Urolithin B ikhonjisiwe ukuthi yeqa isithiyo sobuchopho begazi, futhi ingaba nemiphumela yokuvikela ukuvimbela isifo se-Alzheimer's.

 

I-Urolithin B Powder 1139-83-9 Ucwaningo olwengeziwe

I-Urolithin B inganciphisa ukulimala kwemisipha okwenzeka ngesikhathi sokuzivocavoca okukhulu futhi ivikele imisipha ekucindezelekeni okubangelwa ukudla okunamafutha aphezulu. Ucwaningo lomtholampilo lwe-Urolithin B kumagundane luthole ukuthi lwakhulisa ukukhula kwe-myotubes nokwehlukanisa ngokwandisa amaprotheni synthesis. Kubonise ikhono lokuvimbela indlela ye-ubiquitin – proteasome (UPP), indlela eyinhloko yamaprotheni catabolism. Iphinde yanciphisa imisipha hypertrophy futhi yehlisa imisipha yoma.

Uma kuqhathaniswa ne-testosterone, i-Urolithin B lapho ithathwa ku-15 uM yandisa umsebenzi we-androgen receptor ngo-90% ngenkathi i-testosterone ikwazi ukufeza kuphela umsebenzi owandayo we-receptor we-50% ku-100uM. Lokhu kusho ukuthi kuthatha i-Urolithin B engaphansi kakhulu ukukhulisa umsebenzi we-androgen ngempumelelo ngaphezulu bese inani eliphakeme le-testosterone elandisa umsebenzi we-androgen kancane kahle.

Ngaphezu kwalokho, i-15uM esebenza ngempumelelo kakhulu ye-Urolithin B emikhulu yemisipha yamaprotheni nge-96% uma uyiqhathanisa ne-100uM ye-insulin, equkethe izicubu zamaprotheni emisipha emikhulu ngokusebenzisa ama-61% asebenza kakhulu. Inkolelo yokuthi kuthatha indlela ende kakhulu i-Urolithin B yokwelula ukwakheka kwamaprotheni emisipha ngezinga eliphezulu kakhulu lokusebenza.

Lolu cwaningo lukhombisa ukuthi i-Urolithin B ingavimbela ukubonakala kwamaprotheni ngenkathi ngesikhathi esifanayo inyusa ukwakheka kwamaprotheni, kuyisithako semvelo esisiza ekwakheni izicubu zomzimba ngenkathi kuvimbela ukuwohloka kwemisipha.

 

Isethenjwa se-Urolithin B Powder 1139-83-9

1. 1. UKallio, T., et al: J. Agr. Ukudla Chem., 61, 10720 (2013); UNealmongkol, P., et al.: I-Tetrahedron, 69, 9277 (2013); ULarrosa, M., et al: J. Agr. Ukudla Chem., 54, 1611 (2006); IBialonska, D., et al: J. Agr. Ukudla Chem., 57, 10181 (2009)
2. URodriguez J, et al. Urolithin B, isilawuli esisanda kukhonjwa semisipha yamathambo. Imisipha kaJ Cachexia Sarcopenia. 2017 Aug; 8 (4): 583-597.
3. UBialonska D, uKasimsetty SG, uKhan SI, uFerreira D (11 Novemba 2009). "Ama-Urolithins, ama-metabolites ama-microbial emathunjini wePomegranate ellagitannins, akhombisa umsebenzi onamandla we-antioxidant ekuhlolweni okususelwa kuseli". J Agric Ukudla Chem. 57 (21): 10181-6.