Ukuguga

Ukuguga nokuguga (Ukulwa nokuguga)

Ukuguga yinto sonke esiyenzayo kepha sikuqonda kancane kakhulu ngayo. Ingqondo yakho iba nezinguquko njengoba ukhula ezingaba nemithelela emincane kwimemori yakho noma emakhono okucabanga.Kulula ukwenza uhlu lwazo zonke izinguquko eziza nobudala - ukulahleka kwememori, imibimbi, ukulahleka kwemisipha.
Ukuguga (anti-ukuguga) kungaba yisihloko esinzima ukusidingida: impi okwamanje ilwelwa ngokwencazelo yethemu ekucwaningeni nakwimithi, nanjengemikhiqizo yemikhiqizo enamandla futhi evame ukukhwabanisa
Ukuguga (Anti-ukuguga) manje kunezincazelo eziningi ezejwayelekile ezahlukehlukene kanye nemininingwane.
-Ucwaningweni lwesayensi lokulwa nokuguga komphakathi wesayensi kubhekiselwa kuphela ekunciphiseni, ekunqandeni, noma ekubuyiselweni emuva inqubo yokuguga. Ngenkathi ikusasa libukeka lithembisa kakhulu, okwamanje abukho ubuchwepheshe bezokwelapha obufakazelwe futhi obukhona obuhlisa noma obuyisela emuva ukuguga kubantu.
-Kumphakathi webhizinisi wezokwelapha nodumile, umuthi olwa nokuguga usho ukutholakala, ukuvimbela nokwelashwa kwangaphambi kwesikhathi kwezifo ezihlobene nobudala. Lokhu kuhluke kakhulu ekubhekaneni nenqubo yokuguga uqobo lwayo, futhi kunamasu nezinqubo zokwelapha eziningi ezahlukahlukene okwamanje. Isibonelo ukwelashwa kwe-Alzheimer's, isifo esihlobene nokuguga.
-Kumphakathi wamabhizinisi obanzi - okubandakanya amabhizinisi amaningi enkohliso noma angenamsebenzi - ukulwa nokuguga kungumkhiqizo obalulekile futhi kuyindlela ekhombisiwe yokwandisa ukuthengisa.

Isicelo sokuguga se-powder

Kulesi simo, imikhiqizo yokulwa nokuguga iya ngokuya ithandwa kakhulu. Uhlelo lokusebenza lwe-Anti Old powder lufaka:
-Imikhiqizo yokunakekelwa okuhle
-Imikhiqizo yezempilo enempilo
Iziphuzo ezihlangene
UmkhiqizoPharmaceutical

Ukwelashwa kokuguga ne-Alzheimer's

Cishe i-3% yabantu abaphakathi kweminyaka yobudala engama-65 nengama-74, i-19% phakathi kweminyaka engama-75 nengama-84, futhi cishe isigamu salabo abaneminyaka engaphezu kwengama-85 ubudala banesifo sokuwohloka komqondo. izifo zesifo i-Alzheimer's, isifo se-cerebrovascular, isifo sikaParkinson nesikaLou Gehrig.
Ukuguga kuyimbangela eyinhloko yesifo i-Alzheimer's. I-Alzheimer's uhlobo lokuwohloka komqondo oludala izinkinga ngememori, ukucabanga nokuziphatha. Izimpawu ze-Alzheimer zivame ukukhula kancane futhi ziba zimbi ngokuhamba kwesikhathi, ziba nzima ngokwanele ukuphazamisa imisebenzi yansuku zonke. "Siyazi ukuthi iminyaka yobudala iyona nto eyodwa ebangela isifo i-Alzheimer's, ngakho-ke akumangalisi ukuthi sithole isisetshenziswa sezidakamizwa nakho okubandakanyeka ekugugeni,"
I-FDA ibuye yavuma njengeNamzaric, inhlanganisela yeNamenda (memantine) ne-Aricept, ekwelashweni kwezifo ezinesifo esibucayi esine-Alzheimer's.
INamendais (memantine) okukholelwa ukuthi isebenza ngokulawula i-glutamate, ikhemikhali lobuchopho elibalulekile. Lapho kukhiqizwa ngamanani amaningi, i-glutamate ingaholela ekufeni kweseli yobuchopho. Ngoba abaphikisi beNMDA basebenza ngokuhlukile kuma-inhibitors we-cholineterase, lezi zinhlobo ezimbili zemithi zingabekwa ngokuhlanganiswa.
Imikhiqizo eminingi emisha yaziwa njengelusizo ekwelapheni isifo i-Alzheimer's. Njenge-J-147 powder, i-CMS121 powder.

Imikhiqizo ye-powder eguga

I-J-147 powder (1146963-51-0)I-J147 yinto ethile yesidakamizwa sanamuhla sempilo, kukhonjisiwe ukuthi ilapha isifo i-Alzheimer futhi iguqule ukuguga kumagundane futhi isicishe yalungela ukuhlolwa kwemitholampilo kubantu.Ithimba selivele lenza izifundo ezengeziwe kuma-molecule aguqulwa umphumela we-J147 i-mitochondrial ATP synthase — okungaba yimigomo emisha yezidakamizwa ngokwazo. I-J147 isiqedile ukuhlolwa kwe-toxicology edingekayo ku-FDA ezilwaneni.
I-Alpha-lipoic acid powder (1077-28-7): I-Alpha-lipoic acid ikhemikhali efana nevithamini ebizwa nge-antioxidant, okusho ukuthi ingavikela ubuchopho ngaphansi kwezimo zokulimala noma zokulimala.
I-Alpha-lipoic acid ibonakala isiza ukuvikela izinhlobo ezithile zokulimala kwamaseli emzimbeni, futhi ibuyisa amazinga e-vithamini anjenge-Vitamin E no-Vitamin C. Kunobufakazi futhi bokuthi i-alpha-lipoic acid ingawenza umsebenzi usebenze kahle futhi iqale ukusebenza ngama-neurons kushukela.
Ukulahleka kwememori kuyinkinga ejwayelekile kubantu abadala asebekhulile .Kukholelwa ukuthi ukulimala okuvela ekucindezelweni kwe-oxidative kudlala indima ebalulekile ekulahlekelweni kwememori.
Ngoba i-alpha-lipoic acid iyi-antioxidant enamandla, ucwaningo luye lwahlola ikhono lalo lokwehlisa ukukhula kwezifo ezibonakala ngokulahleka kwememori, njengesifo i-Alzheimer's.
Imvubelo, isibindi, izinso, isipinashi, i-broccoli, namazambane kungumthombo omuhle we-alpha-lipoic acid.
I-CMS121 powder (1353224-53-9): Ama-Geroprotectors yizinto ezinamandla okunciphisa ijubane lapho isilwane sidala ngokukhomba izinqubo zokuguga. Ucwaningo olusha luhlola izinhlanganisela eziningi futhi luhlonza ezinye ezivikela ama-neuron engozini ngokunciphisa inqubo yokuguga; abacwaningi baqamba lezi zinhlanganisela ngama-geroneuroprotectors.
Ngokusebenzisa lezi zinhlanganisela njengesisekelo, abacwaningi basebenzise izidakamizwa ezintathu ze-Alzheimer ezibizwa ngeCMS121, CAD31, neJ147; basebenzise i-fisetin ne-curcumin ngqo. Iqembu likhombisile ukuthi zonke ezinhlanu zalezi zihlanganisi zinciphise ama-biomarker okuguga, zandisa isikhathi sokuphila sezimpuku nezimpukane, futhi sanciphisa nezimpawu zokuwohloka komqondo.

Ukuvela kokuguga

Ukuguga umthelela wesikhathi emzimbeni womuntu, futhi kwenzeka ngamazinga amaningi:
-Cellular ukuguga. Amaseli ubudala ngokuya ngenani lezikhathi eziphindaphindeke ngazo. Iseli lingaphindaphinda izikhathi ezingama-50 ngaphambi kokuthi izinto zofuzo zingabe zisakwazi ukukopishwa ngokunembile, okusho ukuthi ngama-telomeres amafushane. Umonakalo omningi owenziwe kumaseli ngama-radicals wamahhala nangezinye izinto, amangqamuzana amaningi adinga ukuwuphindaphinda.
-Ukuguga kweHormonal. Ama-Horona adlala indima enkulu ekugugeni, ikakhulukazi ngesikhathi sokukhula kwengane nokuvuthwa kobusha. Izinga lama-Hormone liyashintshashintsha empilweni. Ukuthomba kuletha izinduna nama-pores amakhulu. Njengoba sikhula, izinguquko ze-hormonal ziholela esikhumbeni esomile nasekwindabeni yokuya esikhathini.
-Umonakalo owenzekile. Umonakalo oqoqiwe konke kungaphandle. Ukuchayeka ubuthi, ilanga, ukudla okulimazayo, ukungcola kanye nentuthu kuyingozi emzimbeni. Ngokuhamba kwesikhathi, lezi zinto zangaphandle zingaholela ekulimaleni kwezicubu futhi umzimba uwela emuva emandleni alo okugcina nokulungisa amaseli, izicubu nezitho zomzimba.
Ukuguga -Metabolic. Njengoba uqhubeka nosuku lwakho, amangqamuzana akho ahlala eguqula ukudla kube amandla, akhiqiza izinto ezingadala ingozi. Inqubo yokwenza umzimba futhi idale imiphumela yamandla omzimba ngokuhamba kwesikhathi. Abanye bakholelwa ukuthi ukunciphisa ijubane inqubo ye-metabolic ngemikhuba efana nokuvinjelwa kwekhalori kunganciphisa ukuguga kubantu.
Izimpawu ezijwayelekile zokuziphatha kwe-Alzheimer zifaka ukungalali, ukuzulazula, ukuguguleka, ukukhathazeka, ulaka, ukungazweli, nokudangala. Ososayensi bafunda ukuthi kungani lezi zimpawu zenzeka futhi bafunda izindlela zokwelapha ezintsha — izidakamizwa kanye ne-nondrug — ukuzilawula.

Izikhombo:

1. UMortimer RK, uJohnston JR (1959). "Isikhathi Sokuphila Samangqamuzana Emvubelo Ngamunye". Imvelo. 183 (4677): 1751-1752. I-Bibcode: 1959Natur.183.1751M. i-doi: 10.1038 / 1831751a0. i-hdl: 2027 / mdp.39015078535278. I-PMID 13666896
2. Isilingo sokuhlola izidakamizwa ezibhekiswe e-Alzheimer's sikhombisa imiphumela yokulwa nokuguga ”(Press release). ISalk Institute. 12 Novemba 2015. Ibuyiswe ngoNovemba 13, 2015.
3. Abaphenyi bakhomba umgomo wamangqamuzana we-J147, osondela ekuhlolweni kwemitholampilo ukwelapha isifo i-Alzheimer's ”. Kubuyiswe ngo-2018-01-30.
4. Ukulungiswa Kwezinguquko Ze-Alzheimer Disease Neuropathologic With Isimo Sokuqonda: Ukubuyekezwa Kwezincwadi UPeter T. Nelson, u-Irina Alafuzoff, u-Eileen H. Bigio, uConstantin Bouras, uHeiko Braak, uNigel J. Cairns, uRudolph J. Castellani, uBarbara J. Crain, uPeter UDavies, Kelly Del Tredici, Charles Duyckaerts, Matthew P. Frosch, Vahram Haroutunian, Patrick R. Hof, Christine M. Hulette, Bradley T.Hyman, Takeshi Iwatsubo, Kurt A. Jellinger, Gregory A. Jicha, Enikö Kövari, Walter A . Kukull, James B. Leverenz, Seth Love, Ian R. Mackenzie, David M. Mann, Eliezer Masliah, Ann C. McKee, Thomas J. Montine, John C. Morris, Julie A. Schneider, Joshua A. Sonnen, Dietmar R. Thal, John Q. Trojanowski, Juan C. Troncoso, Thomas Wisniewski, Randall L. Woltjer, Thomas G. Beach J Neuropathol Exp Neurol. Umbhalo wesandla; itholakala ku-PMC 2013 Jan 30. Ishicilelwe efomini lokugcina elihleliwe njenge: J Neuropathol Exp Neurol. UNhlaba wezi-2012; 71 (5): 362--381. i-doi: 10.1097 / NEN.0b013e31825018f7

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